Occupational exposure to zeranol, an animal growth promoter

Details

• Personal Author:
  Aw, Tar-Ching ; Glueck CJ ; Smith AB ; Stephenson, Richard L.
• Description:
  A study was made of 11 workers exposed to zeranol (55331298) powder during the manufacturing of the animal growth regulator at the manufacturing facility. The workers included five production and packaging personnel who had regular direct skin contact with the chemical during mixing and sifting of zeranol powder or during packaging of the finished pellets into plastic containers. The other six exposed workers were administrative, laboratory, and cleaning staff with intermittent contact. Exposure was via skin contamination, inhalation, and probably involuntary ingestion as well. An excess of breast symptoms was reported among the male and female workers, but the numbers were small and differences insignificant. No differences were noted regarding intermenstrual bleeding among the exposed and nonexposed women. There was also no impotence, loss of libido, or gynecomastia among the men. Serum luteinizing hormone and follicle stimulating hormone levels in exposed female workers were within normal limits. No differences were found in serum prolactin, estradiol, total cholesterol or in low density lipoprotein cholesterol levels between exposed and nonexposed groups. [Description provided by NIOSH]
• Subjects:
  Dust Endocrine System Occupational Exposure Occupational Health Pharmacies Safety Skin Urogenital System
• Keywords:
  Drugs Dust-inhalation Endocrine-system Hormone-activity NIOSH-Author Occupational-exposure Pharmaceutical-industry Reproductive-system Skin-exposure
• ISSN:
  0007-1072
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  341-346
• Volume:
  46
• Issue:
  5
• NIOSHTIC Number:
  nn:00188418
• Citation:
  Br J Ind Med 1989 May; 46(5):341-346
• CAS Registry Number:
  1H-2-Benzoxacyclotetradecin-1-one, 3,4,5,6,7,8,9,10,11,12-decahydro-7,14,16-trihydroxy-3-methyl- (CAS RN 55331-29-8)
• Federal Fiscal Year:
  1989
• Peer Reviewed:
  True
• Source Full Name:
  British Journal of Industrial Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8d65b5fdc1d416a07ef82519a05411e67354b8663cfc223f36201dc5309c010a8fb353d3851af9b6b908c317d17fee134ed7546e4af0f321ff86e30b1a2decc8
• Download URL:
  https://stacks.cdc.gov/view/cdc/205241/cdc_205241_DS1.pdf
• File Type:
  [PDF - 933.01 KB ]