Monohaloacetic acids

Details

• Description:
  The monohaloacetic acids were reviewed, including information on occupational exposure, physical properties, toxicity, and structure/activity relationships. A detailed review and analysis was conducted of the biological effects of chloroacetic-acid (79118), sodium-chloroacetate (3926623), fluoroacetic-acid (144490), sodium-fluoroacetate (62748), iodoacetic-acid (64697), sodium- iodoacetate (305533), and bromoacetic-acid (79083). Topics included: human effects; epidemiologic studies; animal toxicity; diagnosis; antidotes; absorption, distribution, metabolism, and excretion; biochemistry; mutagenicity; carcinogenicity; and teratogenicity. Accurate information on the number of workers potentially exposed to these compounds was not available. Sodium- fluoroacetate has been widely used as a mammalian pest control agent. Although these compounds have different modes of action, all of them inhibit various metabolic pathways. Based on the acute toxicity to rats, fluoroacetate was the most toxic. [Description provided by NIOSH]
• Subjects:
  Epidemiology Halothane Hazardous Substances Insecticides Occupational Exposure Occupational Health Safety Toxicology
• Keywords:
  Comparative-toxicology Contract-210-79-0091 Halogenated-hydrocarbons NIOSH-Contract Occupational-exposure Pest-control Pesticides Toxic-effects
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Final Contract Report
• Place as Subject:
  Maryland ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-99
• NIOSHTIC Number:
  nn:00207677
• NTIS Accession Number:
  PB92-206077
• Citation:
  Franklin Research Center, Silver Spring, Maryland 1980 Dec; :1-99
• CAS Registry Number:
  Bromoacetic acid (CAS RN 79-08-3) ; Chloroacetic acid (CAS RN 79-11-8) ; Fluoroacetic acid (CAS RN 144-49-0) ; Iodoacetic acid (CAS RN 64-69-7) ; Sodium chloroacetate (CAS RN 3926-62-3) ; Sodium fluoroacetate (CAS RN 62-74-8) ; Sodium iodoacetate (CAS RN 305-53-3)
• Federal Fiscal Year:
  1981
• Peer Reviewed:
  False
• Source Full Name:
  Franklin Research Center, Silver Spring, Maryland
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:67f7512bbb868b7574b00893ecc1622ce702169ff880918d5bcf6809751dfb3ebf01d0171f3b7bac04d673d436d1fb1b02559b310803d630f13ad6bbbf3d4071
• Download URL:
  https://stacks.cdc.gov/view/cdc/205132/cdc_205132_DS1.pdf
• File Type:
  [PDF - 2.25 MB ]