Mechanisms of asbestos and nonasbestiform particles and fibers in bronchogenic carcinoma

Details

• Personal Author:
  Craighead JE ; Mossman BT
• Description:
  The mechanisms underlying asbestos (1332214) and nonasbestos type particles and fibers in the development of bronchogenic carcinoma were investigated. Methods for long term culture of hamster tracheal epithelium after in-vitro exposure to known amounts of minerals were developed. The cocarcinogenicity of the polycyclic aromatic hydrocarbon (PAH) 3-methylcholanthrene (56495) (3MC) after adsorption on crocidolite asbestos (12001284) (CA), carbon (7440440), kaolin (1332587), and hematite (1317608) was determined. It was theorized that the cocarcinogenicity may be related to either affinity of the dust for 3MC, or its elution into the culture medium. However, the relative amounts of 3MC adsorbed and released from the different particulates was not consistently related to tumorigenic potential. This led to an examination and detailed discussion of the concepts of carcinogenesis and the role of promoters. Events in the cellular transformation involved inhibition of normal differentiation, and induction of ornithine- decarboxylase, the rate limiting enzyme. The increased incorporation of thymidine, basal cell hyperplasia, and the appearance of squamous metaplasia in cultured tracheal cells was mentioned. The importance of interactions between PAH and minerals was considered. The authors conclude that asbestos appears to be noncarcinogenic or only weakly carcinogenic in tracheal epithelium unless combined with complete carcinogens such as PAH or cigarette smoke, and that the effects are similar to those of classical tumor promoters. Compared to the nonasbestos type materials, the asbestos type particles increase activation and retention of PAH, thereby increasing the chances of interaction between PAH and DNA, the transformation target. [Description provided by NIOSH]
• Subjects:
  Carcinogens Dust Hydrocarbons Lung Lung Diseases Mining Neoplasms Occupational Exposure Occupational Health Polycyclic Aromatic Hydrocarbons Respiratory System Respiratory Tract Diseases Safety

  More +
• Keywords:
  Carcinogenesis In-vitro-study Lung-cancer Mineral-dusts Miners NIOSH-Grant Occupational-exposure Polycyclic-aromatic-hydrocarbons Pulmonary-system-disorders Respirable-dust
• ISBN:
  9780250406104
• Publisher:
  Butterworth
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Proceedings
• Place as Subject:
  Massachusetts ; OSHA Region 1 ; OSHA Region 8 ; Utah ; Vermont
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  123-134
• NIOSHTIC Number:
  nn:00213851
• Citation:
  Health issues related to metal and nonmetallic mining. Wagner WL, Rom WN, Merchant JA, eds. Boston, MA: Butterworth, 1983 Jan; :123-134
• Contact Point Address:
  Pathology University of Vermont RM a-151 Medical Alumni Bldg Burlington, VT 05405
• CAS Registry Number:
  3-Methylcholanthrene (CAS RN 56-49-5) ; Asbestos (CAS RN 1332-21-4) ; Carbon (CAS RN 7440-44-0) ; Crocidolite asbestos (CAS RN 12001-28-4) ; Hematite (Fe2O3) (CAS RN 1317-60-8) ; Kaolin (CAS RN 1332-58-7)
• Editor(s):
  Wagner WL; Rom WN; Merchant JA
• Federal Fiscal Year:
  1983
• Performing Organization:
  University of Vermont & St Agric College, Burlington, Vermont
• Peer Reviewed:
  False
• Start Date:
  19790901
• Source Full Name:
  Health issues related to metal and nonmetallic mining. Wagner WL, Rom WN, Merchant JA, eds. Boston, MA: Butterworth, 1983 Jan; . Proceedings of the Fourth Annual RMCOEH Occupational and Environmental Health Conference, April 7-9, 1982, Park City, Utah, sponsored by the Rocky Mountain Center for Occupational and Environmental Health
• End Date:
  19820831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5a20a05cfd6b43db6b98f1c2d53a3f124aa5dd58cd4b16d33b04c7be3d787125e7d02aaf475b11d6181a567bc1a6f5a9e69dd26ae8838ea1bdc7c18bdd7131e4
• Download URL:
  https://stacks.cdc.gov/view/cdc/205084/cdc_205084_DS1.pdf
• File Type:
  [PDF - 2.17 MB ]