Investigation of reports of sexual dysfunction among male chemical workers manufacturing stilbene derivatives

Details

• Personal Author:
  Ellenbecker, Michael J. ; Greaves IA ; Hammond K ; Quinn, Margaret M. ; Smith ER ; Spark RF ; Wegman, David H.
• Description:
  NIOSH undertook an investigation to determine if reports of male impotence among a group of chemical workers employed at a large chemical manufacturing factory were work related. The workers at the facility were involved in the manufacture of the stilbene (588590) derivative 4,4'-diaminostilbene-2,2'-disulfonic-acid (81118). The study population consisted of 44 men, aged 20 to 57 years, who were employed at the facility at the time of the investigation. Fourteen percent of the men reported symptoms of impotence over the preceding 6 months or more. Potency problems of a shorter duration were noted by 7%. An additional 7% were not currently impotent but had experienced impotence for 6 or more months in the past. Decreased libido was noted in 36% of the men and all of this was experienced since beginning work in the production area of the firm. Low levels of serum testosterone were observed in 37% of the men. The authors suggest that the exposures to chemical possessing estrogenic activity may be related to the observed health effects in these workers. [Description provided by NIOSH]
• Subjects:
  Endocrine System Hematologic Tests Occupational Health Safety Spermatogenesis Urogenital Diseases Urogenital System Workplace
• Keywords:
  Author Keywords: Impotence Blood-analysis Hormones NIOSH-Cooperative-Agreement NIOSH-Publication Reproductive-effects Reproductive-hazards Reproductive-system-disorders Serum Testosterone Stilbene Manufacture Workplace-studies Workplace Exposures

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• ISSN:
  0271-3586
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; Minnesota ; OSHA Region 1 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  55-68
• Volume:
  18
• Issue:
  1
• NIOSHTIC Number:
  nn:00194961
• Citation:
  Am J Ind Med 1990 Jul; 18(1):55-68
• Contact Point Address:
  Margaret M. Quinn, M.Sc, C.I.H., Department of Work Environment, College of Engineering, University of Lowell, University Avenue, Lowell, MA 01854
• CAS Registry Number:
  Diaminostilbenedisulfonic acid (CAS RN 81-11-8) ; Stilbene (CAS RN 588-59-0)
• Federal Fiscal Year:
  1990
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Industrial Medicine
• End Date:
  19891227
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ec92b34cf9bb891aca9cc0218e4e45251880f8d5bec8711bb5fee938e613d3cbf622cd61ebd4f6e6f2ba0e547269c208a8fc20bbdb0f3e46cf395b75f15c6b52
• Download URL:
  https://stacks.cdc.gov/view/cdc/204982/cdc_204982_DS1.pdf
• File Type:
  [PDF - 849.18 KB ]