Induction of ornithine decarboxylase activity by 4,4'-methylene bis (2-chloroaniline) in the rat

Details

• Personal Author:
  Krieg EF Jr. ; Savage RE Jr. ; Weigel WW ; Krieg EF Jr. ; Savage RE Jr. ; Weigel WW
• Description:
  Induction of hepatic ornithine-decarboxylase (ODC) activity by 4,4'- methylene-bis(2-chloroaniline) (101144) (MOCA) was studied in rats. Male Sprague-Dawley-rats were injected intraperitoneally (ip) once or twice with 0 or 75mg/kg MOCA or once with 0, 15, or 75mg/kg MOCA orally or ip. They were killed 6, 12, 18, 24, 42, or 48 hours after the last dose. Liver cytosol was isolated and assayed for ODC. Maximum induction of ODC activity after a single ip dose of 75mg/kg MOCA occurred 18 hours after injection; activity returned to the control value 42 hours after dosing. In rats that received two 75mg/kg doses, the extent of ODC induction after the second dose was similar to that of the first dose. MOCA at 15mg/kg did not significantly increase ODC activity. Oral induction of ODC activity by 75mg/kg MOCA was less than ip induction but significantly greater than the control value at 18 hours. The authors conclude that MOCA does not cause a prolonged induction of hepatic ODC activity and that the activity is refractory to a second MOCA exposure. [Description provided by NIOSH]
• Subjects:
  Carcinogens Digestive System Laboratories Liver Methylenebis(chloroaniline) Occupational Health Safety
• Keywords:
  Author Keywords: MOCA Biokinetics Carcinogenesis Chlorinated-anilines Dose-response In-vivo-studies Laboratory-animals Liver-enzymes NIOSH-Author Ornithine Decarboxylase Physiological-chemistry

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• ISSN:
  0304-3835
• Document Type:
  Text
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences ; DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  63-68
• Volume:
  62
• Issue:
  1
• NIOSHTIC Number:
  nn:00206237
• Citation:
  Cancer Lett 1992 Feb; 62(1):63-68
• CAS Registry Number:
  3,3′-Dichloro-4,4′-diaminodiphenylmethane (CAS RN 101-14-4) ; 3,3′-Dichloro-4,4′-diaminodiphenylmethane (CAS RN 101-14-4)
• Federal Fiscal Year:
  1992
• Peer Reviewed:
  True
• Source Full Name:
  Cancer Letters
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:cee0e756f7577c8a11ef53fcbe76e1a54d280efad4a722c5511268cd9bd85b7de9c8cbce3d011367b50e8639b3d765f2e4c9245710796d8667262efdcd88b67e
• Download URL:
  https://stacks.cdc.gov/view/cdc/204923/cdc_204923_DS1.pdf
• File Type:
  [PDF - 497.04 KB ]