Exposure-response analysis of cancer mortality in a cohort of workers exposed to ethylene oxide

Details

• Personal Author:
  Elliot L ; Greife, Alice L. ; Halperin, William E. ; Hayes RB ; Hornung, Richard W. ; Morawetz J ; Nowlin S ; Ringenburg, Virginia ; Stayner L ; Steenland, Kyle
• Description:
  The relationship between cancer mortality and the individual estimates of exposure to ethylene-oxide (75218) (EtO) determined using an industrial hygiene based model was studied. The study population included workers from 13 of 14 geographically distinct facilities which had been included in an earlier study. EtO was used regularly to sterilize medical equipment at these facilities beginning between 1938 and 1966 and being used continually through December of 1987. Cancer mortality was examined in three categories of cumulative exposure to EtO. In both the life table analysis and the Cox model, there was a positive trend established in all lymphatic and hematopoietic cancer mortality for cumulative EtO mortality. When exposures to EtO at 10 years prior to death were discounted, and when the analysis was restricted to neoplasms of lymphoid cell origin, the trend appeared to strengthen. The authors conclude that their findings provide support for the hypothesis that EtO exposure increases the risk of mortality resulting from lymphatic and hematopoietic neoplasms. They suggest that the study be continued for follow up using this relatively young cohort. [Description provided by NIOSH]
• Subjects:
  Carcinogens Epidemiology Health Personnel Laboratories Mortality Neoplasms Occupational Exposure Occupational Health Risk Assessment Safety
• Keywords:
  Alkylating-agents Author Keywords: Ethylene Oxide Cancer-rates Health-care-personnel Laboratory-workers Leukemia Mortality Mortality-surveys Neoplasms NIOSH-Author Occupational-exposure Occupational Exposure Risk-analysis

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• ISSN:
  0002-9262
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Ohio ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  138
• Issue:
  10
• NIOSHTIC Number:
  nn:00219752
• Citation:
  Am J Epidemiol 1993 Nov; 138(10):787-798
• Contact Point Address:
  Dr Leslie T. Stayner, National Institute for Occupational Safety and Health, Robert A Taft Laboratories, MS C-15, 4676 Columbia Parkway, Cincinnati, OH 45226
• CAS Registry Number:
  Ethylene oxide (CAS RN 75-21-8)
• Federal Fiscal Year:
  1994
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Epidemiology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:91983b837a87b3a23c187a6fbbc10995da2ec4e862a1740955bec3d9dc660f07392b5f6cd74c73a0bcfb1ed5bee866cae17abc9320522dce1480aec86546cd1f
• Download URL:
  https://stacks.cdc.gov/view/cdc/204747/cdc_204747_DS1.pdf
• File Type:
  [PDF - 840.50 KB ]