Developmental toxicology of industrial alcohols: a summary of 13 alcohols administered by inhalation to rats

Details

• Personal Author:
  Brightwell WS ; Krieg EF Jr. ; Nelson BK
• Description:
  Results were summarized from a series of studies investigating the developmental toxicology of aliphatic alcohols administered by inhalation to rats. The study was undertaken to investigate the hypothesis that the developmental toxicity of the alcohols would increase as carbon chain length increased, up to 6 to 8 carbons, after which the developmental toxicity would decrease. Several of the alcohols, including methanol (67561), 1-propanol (71238), isopropanol (67630), and 1-butanol (71363), produced developmental toxicity in rats when administered by inhalation throughout gestation. However, when developmental toxicity was observed, it was at high concentrations, typically greater than ten times the Permissible Exposure Limits, and generally in the presence of maternal toxicity. Selective developmental toxicity was not apparent. The authors concluded that developmental toxicity would not be induced in rats by inhalation of the alcohol vapors investigated at the concentrations presently permitted in the workplace. There were no effect concentrations determined for 2- butanol (78922) (adult), isopropanol (fetus), 2-butanol (adult), tert-butanol (75650) (adult and fetus), 1-pentanol (71410) (adult), and 2-ethyl-1-hexanol (104767) (adult). The reproductive toxicity to male rats of high concentrations of 1-propanol should be investigated in further studies. [Description provided by NIOSH]
• Subjects:
  Chemistry Fatty Acids Laboratories Occupational Health Respiratory System Safety Urogenital Diseases Urogenital System
• Keywords:
  Aliphatic-compounds Chemical-structure Developmental-disorders Embryopathology Embryotoxicity Inhalation-studies Laboratory-animals NIOSH-Author Reproductive-effects Reproductive-system-disorders
• ISSN:
  0748-2337
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  373-387
• Volume:
  6
• Issue:
  3
• NIOSHTIC Number:
  nn:00197848
• Citation:
  Toxicol Ind Health 1990 May; 6(3-4):373-387
• CAS Registry Number:
  (±)-2-Butanol (CAS RN 78-92-2) ; 1-Butanol (CAS RN 71-36-3) ; 1-Pentanol (CAS RN 71-41-0) ; 1-Propanol (CAS RN 71-23-8) ; 2-Ethylhexanol (CAS RN 104-76-7) ; Isopropanol (CAS RN 67-63-0) ; Methanol (CAS RN 67-56-1) ; tert-Butanol (CAS RN 75-65-0)
• Federal Fiscal Year:
  1990
• NORA Priority Area:
  Reproductive System Disorders
• Peer Reviewed:
  True
• Source Full Name:
  Toxicology and Industrial Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4f9823347907df0ad20f83d2375d405f9756bc7c159164a1697cfe73a6978434d885ac11d3047347a1f911c157eba632998d1ea71a698cc019ee32ff2bbbac3e
• Download URL:
  https://stacks.cdc.gov/view/cdc/204489/cdc_204489_DS1.pdf
• File Type:
  [PDF - 1.68 MB ]