Determinants of restrictive lung function in asbestos-induced pleural fibrosis

Details

• Personal Author:
  Dayton CS ; Galvin JR ; Hunninghake GW ; Merchant, James A. ; Schwartz DA ; Stanford W
• Description:
  Possible causes of restrictive lung function among persons with asbestos (1332214) induced pleural fibrosis were examined for 24 active or retired sheet metal workers with no x-ray evidence of lung parenchymal abnormalities. Seven subjects had radiologically normal pleura, nine circumscribed plaques, and eight had diffuse pleural thickening. Pulmonary function tests, bronchoalveolar lavage and high resolution computed tomographic (HRCT) scans of the lung parenchyma were conducted. Lavage fluid total and differential cell counts were obtained. All subjects were nonsmokers; most were former smokers. Subjects with diffuse pleural thickening had significantly decreased 1 second forced expiratory volumes (FEV1), forced vital capacity (FVC), and total lung capacity (TLC) compared to those with normal pleura. These subjects also had nonsignificantly decreased residual volume (RV) and carbon-monoxide transfer factors (DLcos). Subjects with circumscribed pleural plaques had nonsignificantly decreased FEV1s and FVCs relative to those with normal pleura. RVs and DLcos were similar in the two groups. After controlling for potential confounders, those with diffuse pleural thickening had significantly reduced FVCs, TLCs, and DLcos compared with subjects with normal pleura. Subjects with diffuse pleural thickening were more likely to have a significantly increased percentage of lymphocytes in their lavage fluid, indicative of lymphocytic alveolitis, and HRCT detectable parenchymal fibrosis. These parameters in subjects with circumscribed plaques did not differ significantly from those with normal pleura. After controlling for confounders, univariate analysis revealed that lymphocytic alveolitis was significantly associated with decreased FVC and TLC, but not with HRCT detected parenchymal fibrosis. Multivariate analysis indicated that circumscribed plaques or diffuse pleural thickening were the major factors involved in the decreases of lung volume and DLcos in these subjects. [Description provided by NIOSH]
• Subjects:
  Asbestos Clinical Laboratory Techniques Diagnosis Inorganic Chemicals Lung Metal Workers Occupational Health Radiography Respiratory Function Tests Respiratory System Safety

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• Keywords:
  Asbestosis Chest-X-rays Clinical-diagnosis Clinical-techniques Lung-fibrosis Metal-workers NIOSH-Grant Occupational-medicine Pulmonary-function-tests Statistical-analysis Visual-images

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• ISSN:
  8750-7587
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Iowa ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  68
• Issue:
  5
• NIOSHTIC Number:
  nn:00196695
• Citation:
  J Appl Physiol 1990 May; 68(5):1932-1937
• Contact Point Address:
  Internal Medicine University of Iowa Pulmonary Disease Division Iowa City, IA 52242
• CAS Registry Number:
  Asbestos (CAS RN 1332-21-4)
• Federal Fiscal Year:
  1990
• NORA Priority Area:
  Pulmonary System Disorders
• Performing Organization:
  University of Iowa, Iowa City, Iowa
• Peer Reviewed:
  True
• Start Date:
  19900701
• Source Full Name:
  Journal of Applied Physiology
• End Date:
  19930630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0900f9944aafc1f41e97cd8770391d07d4474d9ebf9e430ae9b69f7619d4a558f70c22231666ac7caf7deb3efd28c6d8e934da493d332b9641754c02bb4e636d
• Download URL:
  https://stacks.cdc.gov/view/cdc/204457/cdc_204457_DS1.pdf
• File Type:
  [PDF - 1.55 MB ]