The clinical relevance of asbestos-induced pleural fibrosis

Details

• Personal Author:
  Schwartz DA
• Description:
  The association between asbestos (1332214) induced pleural fibrosis and parenchymal changes was investigated in 1211 asbestos exposed sheet metal workers. Of those having pleural fibrosis, circumscribed plaques were seen in 260 and diffuse pleural thickening was seen in 74. Pulmonary function testing, high resolution computed tomographic (HRCT) scans of the lung parenchyma, and bronchoalveolar lavage were performed. The presence of circumscribed plaques was related to significant decrements in forced vital capacity (FVC) and one second forced expiratory volume. Workers with diffuse pleural thickening had significant decrements in FVC, total lung capacity (TLC), and carbon-monoxide diffusion capacity (DLco) after controlling for age, years in the trade, and pack years of smoking. This group also exhibited an increased percentage of lymphocytes in their lavage fluid and parenchymal abnormalities on their HRCT scans. Workers with circumscribed plaques also had elevated lavage fluid lymphocyte populations and HRCT parenchymal abnormalities. Circumscribed plaques and diffuse pleural thickening were responsible for a 14% decrease in FVC, a 13% decrease in TLC, and an 11% decrease in DLco. [Description provided by NIOSH]
• Subjects:
  Asbestos Dust Lung Metal Workers Occupational Exposure Occupational Health Radiography Respiratory Function Tests Respiratory System Respiratory Tract Diseases Safety

  More +
• Keywords:
  Asbestos-dust Chest-X-rays Lung-fibrosis Metal-workers NIOSH-Grant Occupational-exposure Pulmonary-function-tests Pulmonary-system-disorders X-ray-analysis
• ISSN:
  0077-8923
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Iowa ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  169-177
• Volume:
  643
• NIOSHTIC Number:
  nn:00207136
• Citation:
  Ann NY Acad Sci 1991 Dec; 643:169-177
• Contact Point Address:
  Internal Medicine University of Iowa Pulmonary Disease Division Iowa City, IA 52242
• CAS Registry Number:
  Asbestos (CAS RN 1332-21-4)
• Federal Fiscal Year:
  1992
• NORA Priority Area:
  Pulmonary System Disorders
• Performing Organization:
  University of Iowa, Iowa City, Iowa
• Peer Reviewed:
  True
• Start Date:
  19900701
• Source Full Name:
  Annals of the New York Academy of Sciences
• End Date:
  19930630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0dbe6b4b08c70dceb05c5e7ac8fa75f15e911e4251076a141b275c7686c2d29894038a625382821347879621cca54c3470a885761cf5fb21af38d25c2304cf5f
• Download URL:
  https://stacks.cdc.gov/view/cdc/205692/cdc_205692_DS1.pdf
• File Type:
  [PDF - 554.48 KB ]