Decreased T cell function in mice exposed to chronic, low levels of lead

Details

• Personal Author:
  Handwerger BS ; McJilton CE ; Neilan BA ; Taddeini L
• Description:
  Splenic B-lymphocytes and T-lymphocytes were quantitated and an evaluation was made of splenic blastogenic responses to both B-cell and T-cell mitogens in mice exposed to low levels of lead (7439921) for 8 week periods. Male C57B1/6-mice, aged 4 to 10 weeks, were administered lead as lead-acetate (15347576) in their drinking water at a concentration of 1300 parts per million. Significantly increased blood lead levels were noted but no change was obvious in weight gain of the mice. A minimal, but statistically significant, decrease in percentages of splenic T-cells and B-cells was noted. The mean response to phytohemagglutinin (PHA) was significantly lower than in controls. The mean response to concanavalin-A (Con-A) was also significantly decreased in the exposed mice. The mean mitogenic response to lipopolysaccharide (LPS) was slightly lower but not significantly so. The decreased number of splenic B-cells and T-cells noted was modest and probably not biologically significant. The markedly diminished mitogenic response to PHA and Con-A but not to LPS, suggested T-lymphocyte function impairment. The authors recommend additional studies of cell mediated immune responses, including assays of T-cell mediated cytotoxicity. [Description provided by NIOSH]
• Subjects:
  Hazardous Substances Hematologic Tests Immune System Laboratories Lead Lead Poisoning Metals, Heavy Occupational Health Safety
• Keywords:
  Blood-analysis Grants-other Heavy-metals Immune-reaction Laboratory-animals Lead-poisoning Long-term-exposure NIOSH-Grant NIOSH-Publication Toxic-effects
• ISSN:
  0009-9104
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Minnesota ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  39
• Issue:
  3
• NIOSHTIC Number:
  nn:00187012
• Citation:
  Clin Exp Immunol 1980 Mar; 39(3):746-749
• Contact Point Address:
  Environmental Health University of Minnesota 1158 Mayo Memorial Minneapolis, Minn 55455
• CAS Registry Number:
  Lead (CAS RN 7439-92-1) ; Lead acetate (CAS RN 15347-57-6)
• Federal Fiscal Year:
  1980
• Performing Organization:
  University of Minnesota of Mnpls-St Paul, Minneapolis, Minnesota
• Peer Reviewed:
  True
• Start Date:
  19770930
• Source Full Name:
  Clinical and Experimental Immunology
• End Date:
  19940630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4c14271b7b813a4d5c89c63af3a3ac25eb477303113e7912986fc3a8007d197ee06257083933848e9dfdbcfdb2e6ca2376b2ea928d485e0762d4bd5fdd69085c
• Download URL:
  https://stacks.cdc.gov/view/cdc/204438/cdc_204438_DS1.pdf
• File Type:
  [PDF - 417.94 KB ]