Comparative cocarcinogenic effects of crocidolite asbestos, hematite, kaolin and carbon in implanted tracheal organ cultures

Details

• Personal Author:
  Craighead JE ; Mossman BT
• Description:
  The cocarcinogenic effects of a fibrous crocidolite (12001284) asbestos and three nonfibrous minerals, hematite (1317608), kaolin (1332587), and carbon (1333864), were assessed after coating the particulates with the polycyclic aromatic hydrocarbon 3- methylcholanthrene (56495) (3MC). Tracheal organ cultures from golden-Syrian-hamsters exposed to the carcinogen treated dusts in- vitro were implanted subsequently into syngeneic animals. The affinity of the particle for the hydrocarbon and uptake of the 3MC by the tracheal epithelium were examined to determine the influence of these factors in carcinogenesis of the respiratory tract. Tumors, primarily carcinomas, appeared after exposure of organ cultures to 3MC coated particles, but not after exposure to the particles themselves. Considering the total number of tumors, the relative cocarcinogenicity of the dusts was crocidolite asbestos, followed by hematite, kaolin, and finally carbon, the least potent in this study. Relatively few carcinomas were found in animals exposed to carbon coated with 3MC. No relationship was noted between carcinogenicity and the affinity of the particle for 3MC or the elution of the hydrocarbon from the dust. The authors suggest that factors other than particle enhanced availability of PAH were important in carcinogenesis in the respiratory tract. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Asbestos Carcinogens Dust Inorganic Chemicals Laboratories Occupational Health Respiratory Tract Diseases Safety
• Keywords:
  Airborne-fibers Asbestos-fibers Control-technology In-vitro-studies In-vivo-studies Laboratory-animals Mineral-dusts NIOSH-Grant NIOSH-Publication Pulmonary-system-disorders
• ISBN:
  9780080268385
• ISSN:
  0003-4878
• Publisher:
  Pergamon Press
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 1 ; Vermont
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  26
• Issue:
  1
• NIOSHTIC Number:
  nn:00192113
• Citation:
  Ann Occup Hyg, Inhaled Particles V, 1982 Sep; 26(1-4):553-567
• Contact Point Address:
  Pathology University of Vermont RM a-151 Medical Alumni Bldg Burlington, VT 05405
• CAS Registry Number:
  3-Methylcholanthrene (CAS RN 56-49-5) ; Carbon black (CAS RN 1333-86-4) ; Crocidolite asbestos (CAS RN 12001-28-4) ; Hematite (Fe2O3) (CAS RN 1317-60-8) ; Kaolin (CAS RN 1332-58-7)
• Editor(s):
  Walton WH
• Federal Fiscal Year:
  1982
• Performing Organization:
  University of Vermont & St Agric College, Burlington, Vermont
• Peer Reviewed:
  True
• Start Date:
  19790901
• Source Full Name:
  Annals of Occupational Hygiene, Inhaled Particles V
• End Date:
  19820831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0161786545ecf0df5ccccecfa8d063cb8f65bd5c2eeb0808db2edd5aeffaafc616262c79603b13ef27846a25c3e7df8c32df52dacd8327881b9dc601deef1977
• Download URL:
  https://stacks.cdc.gov/view/cdc/204360/cdc_204360_DS1.pdf
• File Type:
  [PDF - 3.43 MB ]