Bladder cancer in workers exposed to aniline

Details

• Personal Author:
  Dankovic, David A. ; Tannenbaum SR ; Ward E
• Description:
  Response to and defense of a study on bladder cancer in workers exposed to aniline (62533) were presented. The authors of the original study concluded that ortho-toluidine (95534), not 4- aminobiphenyl (92671), was the major carcinogen underlying the excess incidence of bladder cancer in workers involved in antioxidant manufacturing. Opposition focused on combined evidence favoring 4-aminobiphenyl as the causative agent. Additional information to support the role of ortho-toluidine included: the known carcinogenicity of ortho-toluidine in both mice and rats; the massive quantities of ortho-toluidine used in the manufacture of the antioxidant; the high concentrations of ortho-toluidine observed in air samples and post shift urine samples from exposed workers; and the presence of only trace amounts of 4-aminobiphenyl in bulk samples amounting to less than one part per million. The ratio of the estimated TD50 of 4-aminobiphenyl to that of ortho-toluidine was also considered. The authors concluded that the weight of available evidence favors ortho-toluidine as the major etiologic agent in the excess incidence of bladder cancer. [Description provided by NIOSH]
• Subjects:
  Aniline Compounds Neoplasms Occupational Exposure Occupational Health Safety Toluidines Urogenital Diseases Urogenital System
• Keywords:
  Anilines Bladder-cancer Cancer-rates Employee-exposure Exposure-levels NIOSH-Author Occupational-exposure Worker-health
• ISSN:
  0027-8874
• Document Type:
  Text
• Genre:
  Journal Article
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  83
• Issue:
  20
• NIOSHTIC Number:
  nn:00209920
• Citation:
  J Natl Cancer Inst 1991 Oct; 83(20):1507-1508
• CAS Registry Number:
  4-Aminobiphenyl (CAS RN 92-67-1) ; Aniline (CAS RN 62-53-3) ; o-Toluidine (CAS RN 95-53-4)
• Federal Fiscal Year:
  1992
• Peer Reviewed:
  True
• Source Full Name:
  Journal of the National Cancer Institute
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:60422cf7bc978adef2141e112ed69ff975f4f26f7bc9bd0389f7262d406e009df5e9d67d6a0d9d375eb7a1eb3131d7a97a69552561e00d335a0139d5bb884c8d
• Download URL:
  https://stacks.cdc.gov/view/cdc/204255/cdc_204255_DS1.pdf
• File Type:
  [PDF - 246.01 KB ]