Preventing Bladder Cancer from Exposure to o-Toluidine and Aniline

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  NIOSH has warned that workers exposed to o-toluidine (95534) or aniline (62533) may be at increase risk for developing bladder cancer. Studies on the carcinogenic effects of o-toluidine and aniline in humans and animals were reviewed, and information was presented on the number of workers potentially exposed, and on exposure limits. Epidemiological evidence clearly associated exposure to o-toluidine and aniline with an increased risk of bladder cancer. Risk increased with duration of exposure. Effects of o-toluidine and aniline could not be separated in epidemiological studies. Because o-toluidine induced a greater number and variety of tumors in animals at lower doses than aniline, it was more likely to be responsible for the observed bladder cancers. Recommendations were offered for hazard awareness, training, engineering controls, work practices, the use of personal protective equipment, biological monitoring, and medical screening. [Description provided by NIOSH]
• Subjects:
  Aniline Compounds Carcinogens Coloring Agents Epidemiology Neoplasms Occupational Exposure Occupational Health Safety Toluidines Urogenital Diseases Urogenital System

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• Keywords:
  Anilines Bladder-cancer Cancer-rates Carcinogenesis Dyeing-industry Industrial-hygiene Occupational-exposure
• Series:
  NIOSH Numbered Publications
• DOI:
  https://doi.org/10.26616/NIOSHPUB90116
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; DSDTT - Division of Standards Development and Technology Transfer
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-12
• NIOSHTIC Number:
  nn:00197968
• NTIS Accession Number:
  PB91-188953
• Citation:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 90-116, 1990 Dec; :1-12
• CAS Registry Number:
  Aniline (CAS RN 62-53-3) ; o-Toluidine (CAS RN 95-53-4)
• Federal Fiscal Year:
  1991
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:07f92df9f9de6a1a92cc15e2abed00e322091043da38ca1fe938382a2359ffd942542a0aa2cedb17fcca70e079765297026a0413b9e8b8e6c4788933c3edede5
• Download URL:
  https://stacks.cdc.gov/view/cdc/209616/cdc_209616_DS1.pdf
• File Type:
  [PDF - 992.92 KB ]