Biological monitoring for occupational exposures to ortho-toluidine and aniline

Details

• Personal Author:
  Brown KK ; Cheever KL ; Dankovic D ; DeBord, D. Gayle ; Savage RE ; Stettler, Lloyd E. ; Teass AW ; Ward, Elizabeth M. ; Weigel WW
• Description:
  Biological monitoring methods developed for a NIOSH study of worker exposures to o-toluidine (95534) and aniline (62533) at a facility producing an antioxidant and an accelerator used in tire manufacturing were described. An excess of bladder cancers had been determined among workers at this facility which had been attributed to o-toluidine and aniline exposures. All of the methods developed to measure aniline and o-toluidine in the urine and human albumin relied on the measurement of free amines following base hydrolysis to convert acetylated metabolites in the urine or adducts back to the parent compounds. An analysis of worker urine clearly showed that the uptake of both aniline and o-toluidine occurred in the workplace. The data for o-toluidine were the most striking and indicated that exposed workers were absorbing o-toluidine during the workshift, as the average concentration in the postshift samples compared with the preshift samples was six fold higher. [Description provided by NIOSH]
• Subjects:
  Aniline Compounds Carcinogens Chemistry Hematologic Tests Manufacturing And Industrial Facilities Occupational Health Safety Urine
• Keywords:
  Analytical-methods Anilines Biological-monitoring Blood-analysis Chemical-analysis Chemical-industry-workers NIOSH-Author Urinalysis
• ISSN:
  0355-3140
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences ; DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  78-81
• Volume:
  18
• NIOSHTIC Number:
  nn:00209451
• Citation:
  Scand J Work Environ Health 1992 Jun; 18(Suppl 2):78-81
• Contact Point Address:
  Dr LE Stettler (C-26), National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, Ohio 45226, USA
• CAS Registry Number:
  Aniline (CAS RN 62-53-3) ; o-Toluidine (CAS RN 95-53-4)
• Federal Fiscal Year:
  1992
• Peer Reviewed:
  True
• Source Full Name:
  Scandinavian Journal of Work, Environment & Health
• Supplement:
  2
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:abc08be1d963e2ae653a5816db69a3a7638cbb70b1b5b7aebe926147723d7e53327b6eaa38ff822df6db494348d5ed045682d6fd8f95124f0e978b30f5577d59
• Download URL:
  https://stacks.cdc.gov/view/cdc/204241/cdc_204241_DS1.pdf
• File Type:
  [PDF - 2.56 MB ]