Response of the National Institute for Occupational Safety and Health to an occupational health risk from exposure to ortho- toluidine and aniline

Details

• Personal Author:
  Brown KK ; Fingerhut, Marilyn A. ; Roberts, Dennis R. ; Ruder, Avima M. ; Stettler, Lloyd E. ; Teass AW ; Ward, Elizabeth M.
• Description:
  A health hazard evaluation had been requested by union members regarding possible hazardous exposures at a New York chemical facility as there was an apparent increase in bladder cancer incidence among the rubber additives workers at the site. Nine cases had been diagnosed from 1973 to 1988. Of the several chemicals to which these workers were exposed, only o-toluidine (95534) was classified as an animal carcinogen. An epidemiological study of cancer incidence was conducted, and biomonitoring was used to evaluate exposures. The results of the investigation demonstrated that there was a significant risk of bladder cancer occurring among workers considered to have definite exposure to o- toluidine and aniline (62533), and an intermediate risk among workers considered to have possible exposure. The risks among those definitely exposed increased with length of exposure and time since first exposure. Workers exposed had elevated levels of both chemicals in their urine before the workday began than did unexposed workers. By the end of the workday, these levels were ten to 40 times higher in the exposed workers. A study has recently been initiated by NIOSH to identify a cohort to study bladder cancer incidence among workers exposed only to o-toluidine. Information from the study was under evaluation. [Description provided by NIOSH]
• Subjects:
  Carcinogens Epidemiology Hematologic Tests Manufacturing And Industrial Facilities Neoplasms Occupational Exposure Occupational Health Safety Urine Urogenital Diseases Urogenital System

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• Keywords:
  Biological-monitoring Bladder-cancer Blood-analysis Cancer-rates Chemical-industry-workers NIOSH-Author Occupational-exposure Urinalysis
• ISSN:
  0355-3140
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  New York ; Ohio ; OSHA Region 2 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  82-84
• Volume:
  18
• NIOSHTIC Number:
  nn:00209452
• Citation:
  Scand J Work Environ Health 1992 Jun; 18(Suppl 2):82-84
• Contact Point Address:
  DrAMRuder,NIOSH Taft Labs,Mailstop R-16, 4676 Columbia Parkway, Cincinnati, OH45226, USA
• CAS Registry Number:
  Aniline (CAS RN 62-53-3) ; o-Toluidine (CAS RN 95-53-4)
• Federal Fiscal Year:
  1992
• Peer Reviewed:
  True
• Source Full Name:
  Scandinavian Journal of Work, Environment & Health
• Supplement:
  2
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ddd51072763e78aa3940fef4bcc916e55a4f62b925f0306265931f1f86cf4a0765df70213139cf4ad55048d97252ac7569b673470f001f0e23cc763f1959e950
• Download URL:
  https://stacks.cdc.gov/view/cdc/205529/cdc_205529_DS1.pdf
• File Type:
  [PDF - 2.17 MB ]