Binding of the cationic dye, Janus green B, as a measure of the specific surface area of crystalline silica in aqueous suspension

Details

• Personal Author:
  Daniel LN ; Mao Y ; Saffiotti U ; Vallyathan V
• Description:
  The development of a new binding assay, with a simple and rapid method to obtain surface area measurements which would be applicable to small silica (14808607) samples in an aqueous environment was studied. Reproducible duplicate measurements were obtained on a large number of 2 milligram (mg) samples run concurrently using the Janus-green-B adsorption method. The Brunauer-Emmett-Teller (BET) method necessitated sample sizes in excess of 100mg and more specialized instrumentation. The lowest specific surface areas were found for Min-U-Sil-5 and F600 among four standard alpha-quartz samples tested. Much higher surface areas were observed with DQ-12 and Chinese standard alpha-quartz samples. Cristobalite (14464461) and tridymite (15468323), two synthetic silica preparations, had intermediate surface areas. The authors conclude that binding by Janus-green-B is consistent with a surface charge mechanism and provides a new technique useful in assessing surface characteristics of samples of crystalline silica. The fact that the ratio of aqueous surface charge to surface area is constant for different crystalline silica preparations is suggested by the linear relationship to surface area. The authors note that the relative activities of these silica preparations is important in understanding their roles in the mechanisms of both silicosis and silica induced lung cancer. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Carcinogens Dust Mining Occupational Health Particulate Matter Respiratory Tract Diseases Safety Silicon Dioxide
• Keywords:
  Airborne-dusts Airborne-particles Carcinogenesis Dust-exposure Mineral-dusts Miners NIOSH-Author Respiratory-system-disorders Silica-dusts
• ISSN:
  0041-008X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  62-67
• Volume:
  123
• Issue:
  1
• NIOSHTIC Number:
  nn:00218836
• Citation:
  Toxicol Appl Pharmacol 1993 Nov; 123(1):62-67
• CAS Registry Number:
  Cristobalite (CAS RN 14464-46-1) ; Quartz (SiO2) (CAS RN 14808-60-7) ; Tridymite (SiO2) (CAS RN 15468-32-3)
• Federal Fiscal Year:
  1994
• NORA Priority Area:
  Pulmonary System Disorders
• Peer Reviewed:
  True
• Source Full Name:
  Toxicology and Applied Pharmacology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:366f0178b620ac8167049eef212f3b9ff0300bd5875aec99ad9fd0a50c9e5dd0f75b7748cd5e8683e7275620b9f3b11aae6ca5f08817acf888c6c3723b906b19
• Download URL:
  https://stacks.cdc.gov/view/cdc/204235/cdc_204235_DS1.pdf
• File Type:
  [PDF - 470.05 KB ]