3-Hydroxypropylmercapturic acid: a biologic marker of exposure to allylic and related compounds

Details

• Personal Author:
  Ansari GA ; Boor PJ ; Sanduja R
• Description:
  Urinary excretion of 3-hydroxypropylmercapturic-acid (S-(3- hydroxypropyl)-N-acetyl-L-cysteine) (OHPrMCA) following exposure to allylic compounds was studied in rats to examine the possibility of using OHPrMCA as a biological marker of exposure to allylic compounds that were metabolized to acrolein (107028) and excreted as OHPrMCA in the urine. Male Sprague-Dawley-rats were given 0, 5, 25, 50, 100, or 150mg/kg allylamine-hydrochloride (allylamine), 13mg/kg acrolein (107028), 64mg/kg allylalcohol (107186), 76mg/kg allylchloride (107051), 120mg/kg allylbromide (106956), 115mg/kg allylcyanide (109751), or 160mg/kg cyclophosphamide (50180) by gavage. Twenty four hour urine samples were collected for the next 48 hours and analyzed for OHPrMCA by high performance liquid chromatography. Urine samples from allylamine treated rats contained fairly constant amounts of OHPrMCA, 43.8 to 48.2 percent of the dose being excreted during the first 24 hours and 3 percent during the second 24 hour period. Total urinary excretion of OHPrMCA as a percentage of the dose of the other compounds averaged 78.5 percent for acrolein, 28.3 percent for allylalcohol, 21.5 percent for allylchloride, 3.0 percent for allylbromide, 3.7 percent for allylcyanide, and 2.6 percent for cyclophosphamide. The authors conclude that OHPrMCA may be used as an indicator of exposure to allylic and other compounds that are metabolized to acrolein. [Description provided by NIOSH]
• Subjects:
  Biochemistry Laboratories Occupational Health Safety Sulfur Compounds Urine
• Keywords:
  Acrolein Allylamine Allylic Compounds Author Keywords: 3-hydroxypropylmercapturic Acid Biochemical-indicators Biological-monitoring Biologic Marker Biotransformation Cyclophosphamide Dose-response In-vivo-studies Laboratory-animals NIOSH-Grant NIOSH-Publication Organo-sulfur-compounds Unsaturated-compounds Urinalysis

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• ISSN:
  0260-437X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 6 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  235-238
• Volume:
  9
• Issue:
  4
• NIOSHTIC Number:
  nn:00189864
• Citation:
  J Appl Toxicol 1989 Aug; 9(4):235-238
• Contact Point Address:
  Human Biol Chem and Genetics University of Texas Med BR Dept of Human Biol Chem&gene Galveston, Tex 77550-2774
• CAS Registry Number:
  3-Butenenitrile (CAS RN 109-75-1) ; Acrolein (CAS RN 107-02-8) ; Allyl alcohol (CAS RN 107-18-6) ; Allyl bromide (CAS RN 106-95-6) ; Allyl chloride (CAS RN 107-05-1) ; Cyclophosphamide (CAS RN 50-18-0)
• Federal Fiscal Year:
  1989
• Performing Organization:
  University of Texas Medical Branch, Galveston, Texas
• Peer Reviewed:
  True
• Start Date:
  19860101
• Source Full Name:
  Journal of Applied Toxicology
• End Date:
  19960630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1c5237379d4f901d68664f3be3ef8c1c29b676822d3077689e8597b6df23e2dfbe22537df07375da4098f4ccf2ff9c17849bb7de4959ad3162de4be7e68fa684
• Download URL:
  https://stacks.cdc.gov/view/cdc/203970/cdc_203970_DS1.pdf
• File Type:
  [PDF - 334.26 KB ]