XRF-measured bone lead (Pb) as a biomarker for Pb exposure and toxicity among children diagnosed with Pb poisoning

Details

• Personal Author:
  Hu H ; Lin Y ; Nie LH ; Specht AJ ; Weisskopf M ; Xu J ; Yan C
• Description:
  Childhood lead (Pb) poisoning remains a global issue, especially in industrial areas. In this study, 115 children with average age 5.7 years were recruited as either patient diagnosed with Pb poisoning or controls at Xinhua Hospital in China. The subjects' bone Pb was measured with a K-shell X-ray fluorescence (KXRF) and a portable X-ray fluorescence (XRF) system. A significant correlation between KXRF bone Pb and blood Pb and portable XRF and KXRF measurements were observed. The half-life of blood-lead was calculated to be 9.96 +/- 3.92 d. Our results indicate that bone is a useful biomarker for Pb in children. Description provided by NIOSH
• Subjects:
  • Biomarkers
  • Blood
  • Chemistry
  • Hazardous Substances
  • Hematologic Tests
  • Lead
  • Lead Poisoning
  • Metals
  • Musculoskeletal System
  • Occupational Health
  More +
• Keywords:
  • Lead
  • Lead absorption
  • Lead compounds
  • Lead poisoning
  • Children
  • Metal-compounds
  • Metallic-compounds
  • Bone-structure
  • Biomarkers
  • Toxic effects
  More +
• ISSN:
  1354-750X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Indiana ; Massachusetts ; OSHA Region 1 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  347-352
• Volume:
  21
• Issue:
  4
• NIOSHTIC Number:
  nn:20049302
• Citation:
  Biomarkers 2016 May; 21(4):347-352
• Contact Point Address:
  Linda Nie, School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
• Email:
  hnie@purdue.edu
• CAS Registry Number:
  • Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  2016
• Performing Organization:
  Purdue University, West Lafayette, Indiana
• Peer Reviewed:
  True
• Start Date:
  20120701
• Source Full Name:
  Biomarkers
• End Date:
  20150630
• Download URL:
  https://stacks.cdc.gov/view/cdc/203776/cdc_203776_DS1.pdf
• File Type:
  [PDF - 481.66 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:cca36588abdff30b9c8aa10af0a1eb317ef2db7bb5d231943eb757e4d1ee8ea35c3a166b758a5955a9a8ebd6714edb4ec52fd73fa6a9f0d3eff1bbf8514df042