Urinary polycyclic aromatic hydrocarbon metabolites as biomarkers to woodsmoke exposure - results from a controlled exposure study

Details

• Personal Author:
  Dills RL ; Li Z ; Paulsen M ; Pittman EN ; Riley EA ; Simpson CD ; Sjödin, Andreas ; Trinidad D
• Description:
  Woodsmoke contains harmful components - such as fine particulate matter (PM2.5) and polycyclic aromatic hydrocarbons (PAHs) - and impacts more than half of the global population. We investigated urinary hydroxylated PAH metabolites (OH-PAHs) as woodsmoke exposure biomarkers in nine non-smoking volunteers experimentally exposed to a wood fire. Individual urine samples were collected from 24-h before to 48-h after the exposure and personal PM2.5 samples were collected during the 2-h woodsmoke exposure. Concentrations of nine OH-PAHs increased by 1.8-7.2 times within 2.3-19.3h, and returned to baseline approximately 24 h after the exposure. 2-Naphthol (2-NAP) had the largest post-exposure increase and exhibited a clear excretion pattern in all participants. The level of urinary OH-PAHs, except 1-hydroxypyrene (1-PYR), correlated with those of PM2.5, levoglucosan and PAHs in personal PM2.5 samples. This finding suggests that several urinary OH-PAHs, especially 2-NAP, are potential exposure biomarkers to woodsmoke; by contrast, 1-PYR may not be a suitable biomarker. Compared with levoglucosan and methoxyphenols - two other urinary woodsmoke biomarkers that were measured in the same study and reported previously - OH-PAHs might be better biomarkers based on sensitivity, robustness and stability, particularly under suboptimal sampling and storage conditions, like in epidemiological studies carried out in less developed areas. Description provided by NIOSH
• Subjects:
  • Biomarkers
  • Environmental Exposure
  • Epidemiology
  • Hydrocarbons
  • Occupational Health
  • Particulate Matter
  • Polycyclic Aromatic Hydrocarbons
  • Risk Assessment
  • Risk Factors
  • Safety
  More +
• Keywords:
  • Wood
  • Smoke inhalation
  • Particulates
  • Polycyclic aromatic hydrocarbons
  • Polycyclic hydrocarbons
  • Exposure levels
  • Risk factors
  • Urinalysis
  • Biomarkers
  • Epidemiology
  More +
• ISSN:
  1559-0631
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; OSHA Region 10 ; OSHA Region 4 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  241-248
• Volume:
  26
• Issue:
  3
• NIOSHTIC Number:
  nn:20049140
• Citation:
  J Expo Sci Environ Epidemiol 2016 May-Jun; 26(3):241-248
• Contact Point Address:
  Dr. Zheng Li, National Center for Environmental Health, Center for Disease Control and Prevention, 4770 Buford Highway NE, Atlanta, GA 30341
• Email:
  ZJLi@cdc.gov
• CAS Registry Number:
  • 1-Hydroxypyrene (CAS RN 5315-79-7)
  • 2-Naphthol (CAS RN 135-19-3)
• Federal Fiscal Year:
  2016
• Performing Organization:
  Department of Environmental and Occupational Health Sciences, University of Washington
• Peer Reviewed:
  True
• Start Date:
  20020901
• Source Full Name:
  Journal of Exposure Science and Environmental Epidemiology
• End Date:
  20040831
• Download URL:
  https://stacks.cdc.gov/view/cdc/203696/cdc_203696_DS1.pdf
• File Type:
  [PDF - 420.46 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:73493b59531205f60f1ad6f3c1651b3566a995967beda19b4f3c149896b0c1adb6dcc57476d8737844b080fc17208fe9a738ed7f871834814e3b1ae5b21bad1e