Urinary polycyclic aromatic hydrocarbon metabolites as biomarkers to woodsmoke exposure - results from a controlled exposure study

Details

• Personal Author:
  Dills RL ; Li Z ; Paulsen M ; Pittman EN ; Riley EA ; Simpson CD ; Sjödin, Andreas ; Trinidad D
• Description:
  Woodsmoke contains harmful components - such as fine particulate matter (PM2.5) and polycyclic aromatic hydrocarbons (PAHs) - and impacts more than half of the global population. We investigated urinary hydroxylated PAH metabolites (OH-PAHs) as woodsmoke exposure biomarkers in nine non-smoking volunteers experimentally exposed to a wood fire. Individual urine samples were collected from 24-h before to 48-h after the exposure and personal PM2.5 samples were collected during the 2-h woodsmoke exposure. Concentrations of nine OH-PAHs increased by 1.8-7.2 times within 2.3-19.3h, and returned to baseline approximately 24 h after the exposure. 2-Naphthol (2-NAP) had the largest post-exposure increase and exhibited a clear excretion pattern in all participants. The level of urinary OH-PAHs, except 1-hydroxypyrene (1-PYR), correlated with those of PM2.5, levoglucosan and PAHs in personal PM2.5 samples. This finding suggests that several urinary OH-PAHs, especially 2-NAP, are potential exposure biomarkers to woodsmoke; by contrast, 1-PYR may not be a suitable biomarker. Compared with levoglucosan and methoxyphenols - two other urinary woodsmoke biomarkers that were measured in the same study and reported previously - OH-PAHs might be better biomarkers based on sensitivity, robustness and stability, particularly under suboptimal sampling and storage conditions, like in epidemiological studies carried out in less developed areas. [Description provided by NIOSH]
• Subjects:
  Biomarkers Environmental Exposure Epidemiology Hydrocarbons Occupational Health Particulate Matter Polycyclic Aromatic Hydrocarbons Risk Assessment Risk Factors Safety Urine Wood

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• Keywords:
  1-hydroxypyrene 2-naphthol Author Keywords: Woodsmoke Biomarker Exposure Levels PAH Particulates Polycyclic Aromatic Hydrocarbon Polycyclic Aromatic Hydrocarbons Polycyclic Hydrocarbons Risk Factors Smoke Inhalation Urinalysis

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• ISSN:
  1559-0631
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; OSHA Region 10 ; OSHA Region 4 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  241-248
• Volume:
  26
• Issue:
  3
• NIOSHTIC Number:
  nn:20049140
• Citation:
  J Expo Sci Environ Epidemiol 2016 May-Jun; 26(3):241-248
• Contact Point Address:
  Dr. Zheng Li, National Center for Environmental Health, Center for Disease Control and Prevention, 4770 Buford Highway NE, Atlanta, GA 30341
• Email:
  ZJLi@cdc.gov
• CAS Registry Number:
  1-Hydroxypyrene (CAS RN 5315-79-7) ; 2-Naphthol (CAS RN 135-19-3)
• Federal Fiscal Year:
  2016
• Performing Organization:
  Department of Environmental and Occupational Health Sciences, University of Washington
• Peer Reviewed:
  True
• Start Date:
  20020901
• Source Full Name:
  Journal of Exposure Science and Environmental Epidemiology
• End Date:
  20040831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:73493b59531205f60f1ad6f3c1651b3566a995967beda19b4f3c149896b0c1adb6dcc57476d8737844b080fc17208fe9a738ed7f871834814e3b1ae5b21bad1e
• Download URL:
  https://stacks.cdc.gov/view/cdc/203696/cdc_203696_DS1.pdf
• File Type:
  [PDF - 420.46 KB ]