Non-malignant respiratory disease among workers in industries using styrene - a review of the evidence

Details

• Personal Author:
  Cox-Ganser, Jean M. ; Cummings, Kristin J. ; Huang Y-CT ; Hubbs, Ann F. ; Kreiss, Kathleen ; Nett, Randall J. ; Ruder, Avima M.
• Description:
  Background: Asthma and obliterative bronchiolitis (OB) cases have occurred among styrene-exposed workers. We aimed to investigate styrene as a risk factor for non-malignant respiratory disease (NMRD). Methods: From a literature review, we identified case reports and assessed cross-sectional and mortality studies for strength of evidence of positive association (i.e., strong, intermediate, suggestive, none) between styrene exposure and NMRD-related morbidity and mortality. Results: We analyzed 55 articles and two unpublished case reports. Ten OB cases and eight asthma cases were identified. Six (75%) asthma cases had abnormal styrene inhalation challenges. Thirteen (87%) of 15 cross-sectional studies and 12 (50%) of 24 mortality studies provided at least suggestive evidence that styrene was associated with NMRD-related morbidity or mortality. Six (66%) of nine mortality studies assessing chronic obstructive pulmonary disease-related mortality indicated excess mortality. Conclusions: Available evidence suggests styrene exposure is a potential risk factor for NMRD. Additional studies of styrene-exposed workers are warranted. [Description provided by NIOSH]
• Subjects:
  Asthma Asthma, Occupational Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Styrene

  More +
• Keywords:
  Author Keywords: Styrene Bronchial Asthma Bronchiolitis Bronchiolitis Obliterans Case Reports Cross Sectional Studies Lung Disease Lung Disorders Mortality Studies Non-malignant Respiratory Disease Obliterative Bronchiolitis Occupational Asthma Occupational Lung Disease Pulmonary System Disorders Respiratory System Disorders Risk Factors Styrenes Styrol Vinyl Benzene Vinylbenzene

  More +
• ISSN:
  0271-3586
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  North Carolina ; Ohio ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  RHD - Respiratory Health Division ; HELD - Health Effects Laboratory Division ; DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  163-180
• Volume:
  60
• Issue:
  2
• NIOSHTIC Number:
  nn:20049111
• Citation:
  Am J Ind Med 2017 Feb; 60(2):163-180
• Contact Point Address:
  Randall J. Nett, MD, MPH, Respiratory Health Division, Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), 1095 Willowdale Rd, MS-2800, Morgantown,WV 26505-2888
• Email:
  gge5@cdc.gov
• CAS Registry Number:
  Styrene (CAS RN 100-42-5)
• Federal Fiscal Year:
  2017
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Industrial Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:750d365604771cd7ed599c907a3a5b5cd6ffc923f7786926f0845a27446cdf05c382a3d4ecd23c755ce50b592cc45f358277e17025c4d861c735c666d72bf12d
• Download URL:
  https://stacks.cdc.gov/view/cdc/203679/cdc_203679_DS1.pdf
• File Type:
  [PDF - 315.75 KB ]