Increased sensitivity of OSHA method analysis of diacetyl and 2,3-pentanedione in air

Details

• Personal Author:
  LeBouf, Ryan F. ; Simmons M
• Description:
  Gas chromatography/mass spectrometry (GC/MS) operated in selected ion monitoring mode was used to enhance the sensitivity of OSHA Methods 1013/1016 for measuring diacetyl and 2,3-pentanedione in air samples. The original methods use flame ionization detection which cannot achieve the required sensitivity to quantify samples at or below the NIOSH recommended exposure limits (REL: 5 ppb for diacetyl and 9.3 ppb for 2,3-pentanedione) when sampling for both diacetyl and 2,3-pentanedione. OSHA Method 1012 was developed to measure diacetyl at lower levels but requires an electron capture detector, and a sample preparation time of 36 hours. Using GC/MS allows detection of these two alpha-diketones at lower levels than OSHA Method 1012 for diacetyl and OSHA Method 1016 for 2,3-pentanedione. Acetoin and 2,3-hexanedione may also be measured using this technique. Method quantification limits were 1.1 ppb for diacetyl (22% of the REL), 1.1 ppb for 2,3-pentanedione (12% of the REL), 1.1 ppb for 2,3- hexanedione, and 2.1 ppb for acetoin. Average extraction efficiencies above the limit of quantitation were 100% for diacetyl, 92% for 2,3-pentanedione, 89% for 2,3-hexanedione, and 87% for acetoin. Mass spectrometry with OSHA Methods 1013/1016 could be used by analytical laboratories to provide more sensitive and accurate measures of exposure to diacetyl and 2,3- pentanedione. [Description provided by NIOSH]
• Subjects:
  Butanones Diacetyl Environmental Exposure Environmental Monitoring Laboratories Occupational Health Safety
• Keywords:
  Acetoin Air Sampling Air Sampling Techniques Alpha Particle Detectors Analytical Instruments Analytical Methods Author Keywords: 2,3-pentanedione Chemical Extraction Exposure Assessment Exposure Levels Exposure Limits Gas Chromatography Increased Sensitivity Ketones Laboratory Equipment Laboratory Techniques Mass Spectrometry Measurement Equipment Occupational Safety And Health Administration OSHA OSHA Methods 1013/1016 Recommended Exposure Limits RELs Sampling Sensitivity Testing

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• ISSN:
  1545-9624
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; OSHA Region 8 ; Utah ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  343-348
• Volume:
  14
• Issue:
  5
• NIOSHTIC Number:
  nn:20048872
• Citation:
  J Occup Environ Hyg 2017 May; 14(5):343-348
• Contact Point Address:
  Ryan LeBouf, Field Studies Branch, Respiratory Health Division, National Institute for Occupational Safety and Health
• Email:
  rlebouf@cdc.gov
• CAS Registry Number:
  2,3-Hexanedione (CAS RN 3848-24-6) ; 2,3-Pentanedione (CAS RN 600-14-6) ; Acetoin (CAS RN 513-86-0) ; Butanedione (CAS RN 431-03-8)
• Federal Fiscal Year:
  2017
• NORA Priority Area:
  Healthcare and Social Assistance ; Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Occupational and Environmental Hygiene
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:816b428e27c3a33283f831bcf0b8f83afc8e9b3ef0571a516d3132b59f2a875dabbfdd0507622b473f73aca7ff8d54d29704f198ff97ae02c0e11aa4bba050da
• Download URL:
  https://stacks.cdc.gov/view/cdc/203495/cdc_203495_DS1.pdf
• File Type:
  [PDF - 647.06 KB ]