Integrins: form and role in myofibroblast differentiation and function

Details

• Personal Author:
  Dong J ; Hindman B ; Ma Q
• Description:
  Myofibroblasts play a major role in connective tissue remodeling by synthesizing the extracellular matrix (ECM) and by exerting contraction, both of which depend on complex and specific cell-matrix and cell-cell communications. Integrins are a major family of transmembrane receptors that directly link the intracellular cytoskeleton dynamics to extracellular structures via adhesions in all metazoans. Human integrins are heterodimeric proteins composed of one of the 18 a and one of the eight B subunits to form 24 distinct insoforms. Each integrin has unique, sometimes overlapping, tissue expression, ligands, and functions, and each is capable of cross-interacting with numerous signaling pathways through their intracellular tails and extracellular receptor domains. These structural and functional features enable integrins to transmit both chemical and mechanical signals bidirectionally between cells and the dynamic pericellular environment, which is critical for both physiologic functions, such as embryonic morphogenesis and wound healing, and disease processes, such as organ fibrosis and cancer. Several forms of integrins have been identified in myofibroblasts that seemingly form a core molecular pathway to regulate the differentiation and function of myofibroblasts in physiology and disease. In this chapter, we discuss major integrins that have an established role in the formation, function and turnover of myofibroblasts associated with tissue remodeling. Particular attention is given to B1- and av-containing integrins relating to their role and mode of action in myofibroblast activation during wound healing and organ fibrosis. [Description provided by NIOSH]
• Subjects:
  Environment Fibrosis Microbiology Neoplasms Occupational Health Safety
• Keywords:
  A-SMA Adhesion Author Keywords: Myofibroblast Cancer Cell Function Cellular Function Cellular Reactions ECM Environmental Factors Fibroblasts Integrin Molecular Biology Proteins TGF-B Tumors Wound Healing

  More +
• ISBN:
  9781634857437
• Publisher:
  Nova Science Publishers, Inc.
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-27
• NIOSHTIC Number:
  nn:20048841
• Citation:
  Myofibroblasts origin, function and role in disease. Martinez A,, ed. New York: Nova Science Publishers, Inc., 2016 Sep; :1-27
• Contact Point Address:
  Qiang Ma, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, 1095 Willowdale Rd, Morgantown, WV 26505
• Email:
  qam1@cdc.gov
• Editor(s):
  Martinez A
• Federal Fiscal Year:
  2016
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  Myofibroblasts origin, function and role in disease
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8dd86de04bfe9456047a4a2018084e358b2abaf1261e28f119b0ca38752f7dda713b665cf0d6af7033007bdb39042e010a75b170016466895aed1a84b8a35dd6
• Download URL:
  https://stacks.cdc.gov/view/cdc/203469/cdc_203469_DS1.pdf
• File Type:
  [PDF - 6.99 MB ]