New approaches to wipe sampling methods for antineoplastic and other hazardous drugs in healthcare settings

Details

• Personal Author:
  Connor, Thomas H. ; Smith JP
• Description:
  Purpose: At the present time, the method of choice to determine surface contamination of the workplace with antineoplastic and other hazardous drugs is surface wipe sampling and subsequent sample analysis with various analytical techniques. The purpose of this article is to review current methodology for determining the level of surface contamination with hazardous drugs in healthcare settings and to discuss recent advances in this area. In addition it will provide some guidance for conducting surface wipe sampling and sample analysis for these drugs in healthcare settings. Methods: Published studies on the use of wipe sampling to measure hazardous chemicals, including antineoplastic drugs on surfaces were reviewed. These studies include the use of well-documented chromatographic techniques for sample analysis in addition to newly evolving technology that provides rapid analysis of specific antineoplastic drugs. Results: Methodology for the analysis of surface wipe samples for hazardous drugs are reviewed, including the purposes, technical factors, sampling strategy, materials required, and limitations. The use of lateral flow immunoassay (LFIA) and fluorescence covalent microbead immunosorbent assay (FCMIA) for surface wipe sample evaluation is also discussed. Conclusions: Current recommendations are that all healthcare settings where antineoplastic and other hazardous drugs are handled include surface wipe sampling as part of a comprehensive hazardous drug-safe handling program. Surface wipe sampling may be used as a method to characterize potential occupational dermal exposure risk and to evaluate the effectiveness of implemented controls and the overall safety program. New technology, although currently limited in scope, may make wipe sampling for hazardous drugs more routine, less costly, and provide a shorter response time than classical analytical techniques now in use. Description provided by NIOSH
• Subjects:
  • Chromatography
  • Hazardous Substances
  • Health Care Facilities Workforce and Services
  • Health Personnel
  • Laboratories
  • Manufacturing and Industrial Facilities
  • Occupational Exposure
  • Occupational Health
  • Risk Assessment
  • Risk Factors
  More +
• Keywords:
  • Analytical methods
  • Antineoplastic agents
  • Hazardous drugs
  • Sampling
  • Risk factors
  • Dermal exposures
  • Dermal absorption
  • Drugs
  • Health care facilities
  • Medical facilities
  More +
• ISSN:
  2365-242X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  107-114
• Volume:
  1
• Issue:
  3
• NIOSHTIC Number:
  nn:20048652
• Citation:
  Pharm Technol Hosp Pharm 2016 Sep; 1(3):107-114
• Contact Point Address:
  Thomas H. Connor, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45226
• Email:
  tmc6@cdc.gov
• Federal Fiscal Year:
  2016
• NORA Priority Area:
  Healthcare and Social Assistance
• Peer Reviewed:
  True
• Source Full Name:
  Pharmaceutical Technology in Hospital Pharmacy
• Download URL:
  https://stacks.cdc.gov/view/cdc/203360/cdc_203360_DS1.pdf
• File Type:
  [PDF - 4.84 MB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:621703d83b8542d852b99e34dc2700b8be43a64b11788769f55034428f69daaec1827c0e9a9e0ed18b439c9daf814508e8a244431aceadf6b3cac8db23800ae5