Obesity and oxidative stress among police officers

Details

• Personal Author:
  Andrew, Michael E. ; Browne RW ; Burchfiel CM ; Charles LE ; Fekedulegn D ; Hartley TA ; Slaven, James E. ; Voilanti JM
• Description:
  Background and aims: Police officers are affected by the obesity pandemic. Obesity is associated with cardiovascular disease and the biological mechanism may involve oxidative stress. The authors investigated the association between several anthropometric measures (BMI, waist circumference, waist-to- hip ratio, waist-to-height ratio, and abdominal height) and biomarkers of oxidative stress (glutathione (GSH), glutathione peroxidase (GSH-Px), vitamin C, thiobarbituric acid reactive substances (TBARS), and trolox equivalent antioxidant capacity (TEAC)) among police officers. Methods: This cross-sectional study included 110 randomly selected police officers (44 women and 66 men) from Buffalo, New York. Anthropometric measures were performed by clinic staff and standardized testing of the biomarkers was performed on fasting blood specimens. An oxidative stress score (OSS) variable was created as a composite of the biomarkers. Analyses of variance and covariance were used to compare mean levels of each oxidative stress marker across tertiles of the anthropometric measures. Results: Officers ranged in age from 26 to 61 years, mean +/- SD = 39.6 +/- 7.6 years. GSH was inversely and significantly associated with waist circumference (trend p = 0.002) and waist-to-hip ratio (trend p = 0.001). These associations remained significant after adjustment for age, sex, education, smoking, alcohol, and physical activity. Additional adjustment for BMI did not attenuate the results. GSH-Px was inversely and significantly associated with BMI (adjusted trend p = 0.002) and with waist-to-height ratio (adjusted trend p = 0.007). Mean levels of vitamin C were inversely, but not significantly, associated with waist-to-height ratio. Mean levels of TEAC, TBARS, or OSS were not associated with any of the anthropometric measures. Significant interactions were observed for physical activity with (a) waist circumference and waist-to-hip ratio for GSH and (b) all anthropometric measures (except abdominal height) for vitamin C. The above associations were inversely related only among officers who reported engaging in some physical activity. Significant inverse associations were observed for waist circumference and waist-to-hip ratio with vitamin C, but only among never smokers; the interaction with smoking status was significant. Discussion and conclusions: Obesity was significantly associated with several markers of oxidative stress and these associations showed significant interactions with physical activity and smoking. [Description provided by NIOSH]
• Subjects:
  Aging Biomarkers Blood Body Weight Cardiovascular Diseases Cardiovascular System Hematologic Tests Law Enforcement Men Occupational Health Safety Smokers Women

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• Keywords:
  Age Groups Blood Samples BMI Body Mass Index Body Weight Cardiovascular Disease Cardiovascular System Cardiovascular System Disease Cardiovascular System Disorders Humans Obesity Oxidative Stress Physical Exercise Police Officers Smoking Stress

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• ISSN:
  1351-0711
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  65
• Issue:
  9
• NIOSHTIC Number:
  nn:20048354
• Citation:
  Occup Environ Med 2008 Sep; 65(9)(Suppl):166 Tu-P-1
• Federal Fiscal Year:
  2008
• Peer Reviewed:
  False
• Source Full Name:
  Occupational and Environmental Medicine. EPICOH 2008
• Supplement:
  Suppl
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0a28aafa782565425db21876506b81d5dded91582df9c917af0c3fcae9518c34b846fcbb06d8c7459103a55b8eafdae801f299f95743228ddcd943c65ecc2779
• Download URL:
  https://stacks.cdc.gov/view/cdc/203122/cdc_203122_DS1.pdf
• File Type:
  [PDF - 40.98 KB ]