Leptin, adiponectin, and heart rate variability among police officers

Details

• Personal Author:
  Andrew M ; Burchfiel C ; Charles L ; Fekedulegn D ; Gu J ; Li S ; Sarkisian K ; Violanti J
• Description:
  Objectives: To investigate the relationship of leptin and adiponectin with heart rate variability (HRV). Method: Leptin and adiponectin levels were measured in 388 non-diabetic officers from the Buffalo Cardio-Metabolic Occupational Police Stress study, following a 12-hour fast. HRV was performed according to methods published by the Task Force of the European Society of Cardiology and the North American Society of Pacing Electrophysiology for measurement and analysis of HRV. Mean values of high (HF) and low frequency (LF) HRV were compared across tertiles of leptin and adiponectin using ANOVA and ANCOVA; trends were assessed using linear regression models. Results: Leptin, but not adiponectin, was significantly and inversely associated with HF and LF HRV. BMI and percent body fat (also waist circumference and abdominal height) significantly modified the association between leptin and LF (but not HF) HRV. Among officers with BMI <25 kg/m2, the association between leptin and HRV was not significant. However, among officers with BMI >=25 kg/m2, the association between leptin and HRV was inversely related, after adjustment for age, gender, and race/ethnicity; p-values for trend (HF HRV, p = 0.019 and LF HRV, p < 0.0001). Similarly, among officers with percent body fat >=25.5%, leptin and LF HRV showed significant, inverse associations (adjusted p for trend = 0.001). Conclusions: Our results show that leptin levels were inversely and significantly associated with HRV among all officers, and particularly among officers with higher levels of adiposity. These results suggest that increased leptin levels may be associated with CVD-related health problems. [Description provided by NIOSH]
• Subjects:
  Aging Body Weight Cardiovascular Diseases Cardiovascular System Endocrine System Epidemiology Law Enforcement Men Occupational Health Race Factors Safety Women Workplace

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• Keywords:
  Age-groups Body-weight Cardiac-function Cardiovascular-disease Cardiovascular-function Cardiovascular-system Cardiovascular-system-disease Cardiovascular-system-disorders Heart Heart-rate Hormones Humans Law-enforcement-workers Police-officers Proteins Racial-factors Sociological-factors Statistical-analysis Stress Weight-factors Work-environment Workers

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• ISSN:
  1351-0711
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  Illinois ; New York ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 5 ; Pennsylvania ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  71
• NIOSHTIC Number:
  nn:20044615
• Citation:
  Occup Environ Med 2014 Jun; 71(Suppl 1):A65-A66
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Public Safety
• Peer Reviewed:
  False
• Source Full Name:
  Occupational and Environmental Medicine. Challenges for Occupational Epidemiology in the 21st Century, EPICOH 2014, June 24-27, 2014, Chicago, Illinois
• Supplement:
  1
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:51e48209e3928ce77acf04ff1ffe04e6e0b9ce76f9b23f01b5955a6050028b9863421b31a04f2d6c769aca3def2b19b4b4449e0c6563429a4c1a7629845709fd
• Download URL:
  https://stacks.cdc.gov/view/cdc/200282/cdc_200282_DS1.pdf
• File Type:
  [PDF - 81.03 KB ]