Toxicities associated with the occupational life cycle of MWCNT

Details

• Personal Author:
  Battelli L ; Bishop L ; Bunker K ; Casuccio G ; Cena L ; Dahm, Matthew M. ; Erdely A ; Eye T ; Kang J ; Kodali V ; Mercer RR ; Orandle M ; Sager T ; Sargent LM ; Scabilloni J ; Schubauer-Berigan, Mary K. ; Schwegler-Berry D ; Stefaniak, Aleksandr B. ; Zeidler-Erdely PC ; Battelli L ; Bishop L ; Bunker K ; Casuccio G ; Cena L ; Dahm, Matthew M. ; Erdely A ; Eye T ; Kang J ; Kodali V ; Mercer RR ; Orandle M ; Sager T ; Sargent LM ; Scabilloni J ; Schubauer-Berigan, Mary K. ; Schwegler-Berry D ; Stefaniak, Aleksandr B. ; Zeidler-Erdely PC
• Description:
  Companies synthesize or purchase as-produced multi-walled carbon nanotubes (AP-MW), apply a commercial or proprietary polymer coating (PC-MW), then embed the PC-MW into a composite matrix. Since workers are potentially exposed at each production stage, we evaluated the toxicity profile of these materials. Initially, male C57BL/6J mice aspirated 4 or 40 microg AP-MW or PC-MW using preparations to emulate personal breathing zone collections. Bronchoalveolar lavage and tissues were collected at 4 h, 1, 7, 28 and 84 d post-exposure. While the AP-MW induced dose- and time-dependent measures of pulmonary cytotoxicity and inflammation, applied polymer coatings did not enhance those effects. Histopathologic changes included small granulomas at terminal bronchioles at 84 d but no significant alveolar fibrosis at the 40 microg dose. The material was significantly aggregated and unlike larger diameter multi-walled carbon nanotubes (MW), no translocation to systemic organs was detected. Lastly, composites with 0.15% and 3% PC-MW by weight were subjected to an industrial sanding process. Assessment of generated aerosols show primarily micrometer-sized particles with some MW protrusions. No evidence of free MW was observed. Interestingly, the characteristics of the base composite material itself and the addition of PC-MW affect the particle number, and subsequently, the respirable fraction of the generated aerosol. These findings provide insight on the toxicity at different stages of the MW production and suggest that while the number of people potentially exposed increases along the product value chain during this kind of production process, the potential for MW exposure greatly decreases. [Description provided by NIOSH]
• Subjects:
  Aerosols Cytotoxins Environmental Exposure Hazardous Substances Immune System Laboratories Lung Lung Diseases Occupational Health Polymers Respiratory System Respiratory Tract Diseases Safety Toxicology

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• Keywords:
  Aerosol Particles Author Keywords: Carbon-based Nanomaterials Biological-effects Breathing Zone Coatings Cytotoxicity Exposure Assessment Exposure Levels Health-hazards Histopathology Immune Reaction Laboratory Animals Laboratory Testing Life Cycle Analysis Multi-walled Carbon Nanotubes MWCNT Nanomaterial Release Nanomaterials Nanoparticles Nanotechnology Nanotoxicology Nanotubes Occupational Safety Pulmonary Function Pulmonary System Pulmonary System Disorders Ultrafine-particulates

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• Publisher:
  International Nanotoxicology Congress
• Document Type:
  Text
• Genre:
  Abstract or Summary ; Abstract or Summary
• Place as Subject:
  Massachusetts ; Ohio ; OSHA Region 1 ; OSHA Region 3 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; RHD - Respiratory Health Division ; HELD - Health Effects Laboratory Division ; DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  53
• NIOSHTIC Number:
  nn:20048167
• Citation:
  nanoTOX 2016, Proceedings of the 8th International Nanotoxicology Congress, June 1-4, 2016, Boston, Massachusetts. Boston: MA: International Nanotoxicology Congress, 2016 Jun; :53
• CAS Registry Number:
  Carbon nanotubes (CAS RN 308068-56-6) ; Carbon nanotubes (CAS RN 308068-56-6)
• Federal Fiscal Year:
  2016
• NORA Priority Area:
  Manufacturing ; Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  nanoTOX 2016, Proceedings of the 8th International Nanotoxicology Congress, June 1-4, 2016, Boston, Massachusetts
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2fff2f293fa9acacbd259a0d2c65dfbc2e89c3cd60282581244f7f113776abb2273f0efe62600438f73b2e38ecf116bcf5694a55c1e927e6983f9be9b7b7de3d
• Download URL:
  https://stacks.cdc.gov/view/cdc/202989/cdc_202989_DS1.pdf
• File Type:
  [PDF - 325.37 KB ]