Association of MHC region SNPs with irritant susceptibility in healthcare workers

Details

• Personal Author:
  Barmada MM ; Baron E ; Fluharty K ; Frye B ; Germolec D ; Gharib R ; Johnson VJ ; Kashon ML ; Luster MI ; Meade J ; Nedorost S ; Talzhanov Y ; Wang W ; Wilson NW ; Yucesoy, Berran
• Description:
  Irritant contact dermatitis is the most common work-related skin disease, especially affecting workers in "wet-work" occupations. This study was conducted to investigate the association between single nucleotide polymorphisms (SNPs) within the major histocompatibility complex (MHC) and skin irritant response in a group of healthcare workers. 585 volunteer healthcare workers were genotyped for MHC SNPs and patch tested with three different irritants: sodium lauryl sulfate (SLS), sodium hydroxide (NaOH) and benzalkonium chloride (BKC). Genotyping was performed using Illumina Goldengate MHC panels. A number of SNPs within the MHC Class I (OR2B3, TRIM31, TRIM10, TRIM40 and IER3), Class II (HLA-DPA1, HLA-DPB1) and Class III (C2) genes were associated (p<0.001) with skin response to tested irritants in different genetic models. Linkage disequilibrium patterns and functional annotations identified two SNPs in the TRIM40 (rs1573298) and HLA-DPB1 (rs9277554) genes, with a potential impact on gene regulation. In addition, SNPs in PSMB9 (rs10046277 and ITPR3 (rs499384) were associated with hand dermatitis. The results are of interest as they demonstrate that genetic variations in inflammation-related genes within the MHC can influence chemical-induced skin irritation and may explain the connection between inflamed skin and propensity to subsequent allergic contact sensitization. [Description provided by NIOSH]
• Subjects:
  Genetics Health Personnel Occupational Health Safety Skin Skin Diseases
• Keywords:
  Author Keywords: Genetics Contact Dermatitis Genes Health Care Workers Healthcare Workers Irritant Contact Dermatitis MHC Skin Diseases Skin Irritants
• ISSN:
  1547-691X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Nevada ; North Carolina ; Ohio ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 9 ; Pennsylvania ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  13
• Issue:
  5
• NIOSHTIC Number:
  nn:20048111
• Citation:
  J Immunotoxicol 2016 Sep; 13(5):738-744
• Contact Point Address:
  Berran Yucesoy, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA
• Email:
  berranyucesoy@gmail.com
• Federal Fiscal Year:
  2016
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Immunotoxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:95fe3431117cc2cff23d0ee801b219173b252641094d90f30470c79452d2f0823f8e2961ef2bdc0b18ce3bdffbd84a6a28ee4fcf137243dc038bf20223e28219
• Download URL:
  https://stacks.cdc.gov/view/cdc/202972/cdc_202972_DS1.pdf
• File Type:
  [PDF - 808.71 KB ]