Respirable indium exposures, plasma indium, and respiratory health among indium-tin oxide (ITO) workers

Details

• Personal Author:
  Carey B ; Cummings, Kristin J. ; Edwards, Nicole T. ; Kreiss, Kathleen ; Park JY ; Stanton, Marcia L. ; Stefaniak, Aleksandr B. ; Trapnell BC ; Virji, M. Abbas
• Description:
  Background: Workers manufacturing indium-tin oxide (ITO) are at risk of elevated indium concentration in blood and indium lung disease, but relationships between respirable indium exposures and biomarkers of exposure and disease are unknown. Methods: For 87 (93%) current ITO workers, we determined correlations between respirable and plasma indium and evaluated associations between exposures and health outcomes. Results: Current respirable indium exposure ranged from 0.4 to 108ug/m3 and cumulative respirable indium exposure from 0.4 to 923ug-yr/m3. Plasma indium better correlated with cumulative (rs=0.77) than current exposure (rs=0.54) overall and with tenure >1.9 years. Higher cumulative respirable indium exposures were associated with more dyspnea, lower spirometric parameters, and higher serum biomarkers of lung disease (KL-6 and SP-D), with significant effects starting at 22ug-yr/m3, reached by 46% of participants. Conclusions: Plasma indium concentration reflected cumulative respirable indium exposure, which was associated with clinical, functional, and serum biomarkers of lung disease. [Description provided by NIOSH]
• Subjects:
  Biomarkers Blood Chemistry Environmental Exposure Indium Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Workplace

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• Keywords:
  Author Keywords: Indium-tin Oxide Chemical Composition Chemical Properties Cumulative Exposure Exposure Levels Indium Compounds KL-6 Lung Disease Pulmonary System Pulmonary System Disorders Respiratory Diseases Respiratory System Disorders Risk Factors SP-D Spirometry Work Environment Workers

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• ISSN:
  0271-3586
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 3 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  59
• Issue:
  7
• NIOSHTIC Number:
  nn:20048052
• Citation:
  Am J Ind Med 2016 Jul; 59(7):522-531
• Contact Point Address:
  Kristin J. Cummings, MD, MPH, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, MS 2800, Morgantown, WV 26505
• Email:
  kcummings@cdc.gov
• CAS Registry Number:
  Indium (CAS RN 7440-74-6) ; Indium tin oxide (In1.69Sn0.15O2.85) (CAS RN 71243-84-0)
• Federal Fiscal Year:
  2016
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Industrial Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b43ef1f988d0bcedd10796e7045aeec646c291b7b8f5d6f9530df0082ed027e21402a155e2c55984006b2122f061d7e588cd8181bc1249ee13efb47db34bf705
• Download URL:
  https://stacks.cdc.gov/view/cdc/202928/cdc_202928_DS1.pdf
• File Type:
  [PDF - 447.22 KB ]