Bridging the gap between exposure assessment and inhalation toxicology: some insights from the carbon nanotube experience

Details

• Personal Author:
  Antonini JM ; Chen BT ; Dahm, Matthew M. ; Erdely A ; Hoover, Mark D. ; Schubauer-Berigan, Mary K.
• Description:
  The early incorporation of exposure assessment can be invaluable to help design, prioritize, and interpret toxicological studies or outcomes. The sum total of the exposure assessment findings combined with preliminary toxicology results allows for exposure-informed toxicological study design and the findings can then be integrated, together with available epidemiologic data, to provide health effect relevance. With regard to engineered nanomaterial inhalation toxicology in particular, a single type of material (e.g. carbon nanotube, graphene) can have a vast array of physicochemical characteristics resulting in the potential for varying toxicities. To compound the matter, the methodologies necessary to establish a material adequate for in vivo exposure testing raises questions on the applicability of the outcomes. From insights gained from evaluating carbon nanotubes, we recommend the following integrated approach involving exposure-informed hazard assessment and hazard-informed exposure assessment especially for materials as diverse as engineered nanomaterials: 1) market-informed identification of potential hazards and potentially exposed populations, 2) initial toxicity screening to drive prioritized assessments of exposure, 3) development of exposure assessment-informed chronic and sub-chronic in vivo studies, and 4) conduct of exposure- and hazard-informed epidemiological studies. [Description provided by NIOSH]
• Subjects:
  Chemistry Epidemiology Occupational Health Respiratory System Safety Toxicology
• Keywords:
  Author Keywords: Exposure Assessment Carbon Nanotube Carbon Nanotubes Chemical Properties Exposure Assessment Health Effects Inhalation Nanomaterial Nanomaterials Physical Properties
• ISSN:
  0021-8502
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 3 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  157-162
• Volume:
  99
• NIOSHTIC Number:
  nn:20048006
• Citation:
  J Aerosol Sci 2016 Sep; 99:157-162
• Contact Point Address:
  Aaron Erdely, Health Effects Laboratory Division, NIOSH/HELD/PPRB, 1095 Willowdale Rd, MS-2015, Morgantown, WV 26505
• Email:
  efi4@cdc.gov
• Federal Fiscal Year:
  2016
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Aerosol Science
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:708e30a4f3e05bbc5e8fdba75f8dc1f5258aa9926b32a9999c7a45c97a427e6f30ef8acfacd7d4ea19fc11813b25d0d3e7c5e53ac5e3bb6ec2148e32320d2808
• Download URL:
  https://stacks.cdc.gov/view/cdc/202897/cdc_202897_DS1.pdf
• File Type:
  [PDF - 611.45 KB ]