Impact of missing data for body mass index in an epidemiologic study

Details

• Personal Author:
  Herring AH ; Howards PP ; Johnson CY ; Razzaghi H ; Tinker SC ; Waller DK
• Corporate Authors:
  National Birth Defects Prevention Network
• Description:
  Objective: To assess the potential impact of missing data on body mass index (BMI) on the association between prepregnancy obesity and specific birth defects. Methods: Data from the National Birth Defects Prevention Study (NBDPS) were analyzed. We assessed the factors associated with missing BMI data among mothers of infants without birth defects. Four analytic methods were then used to assess the impact of missing BMI data on the association between maternal prepregnancy obesity and three birth defects; spina bifida, gastroschisis, and cleft lip with/without cleft palate. The analytic methods were: (1) complete case analysis; (2) assignment of missing values to either obese or normal BMI; (3) multiple imputation; and (4) probabilistic sensitivity analysis. Logistic regression was used to estimate crude and adjusted odds ratios (aOR) and 95% confidence intervals (CI). Results: Of NBDPS control mothers 4.6 % were missing BMI data, and most of the missing values were attributable to missing height (approximately 90%). Missing BMI data was associated with birth outside of the US (aOR 8.6; 95% CI 5.5, 13.4), interview in Spanish (aOR 2.4; 95% CI 1.8, 3.2), Hispanic ethnicity (aOR 2.0; 95% CI 1.2, 3.4), and <12 years education (aOR 2.3; 95% CI 1.7, 3.1). Overall the results of the multiple imputation and probabilistic sensitivity analysis were similar to the complete case analysis. Conclusions: Although in some scenarios missing BMI data can bias the magnitude of association, it does not appear likely to have impacted conclusions from a traditional complete case analysis of these data. [Description provided by NIOSH]
• Subjects:
  Case Reports Digestive System Digestive System Diseases Epidemiology Occupational Health Pregnancy Race Factors Risk Assessment Risk Factors Safety Women

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• Keywords:
  Abdomen Analytical Methods Author Keywords: Birth Defect Birth Defects BMI Body Mass Index Case Studies Gastrointestinal System Disorders Health Care Missing BMI Missing Data NBDPS Obesity Oral Cavity Oral Disorders Racial Factors Recordkeeping Risk Assessment Risk Factors Spinal Cord Disorders

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• ISSN:
  1092-7875
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; North Carolina ; Ohio ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 6 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  20
• Issue:
  7
• NIOSHTIC Number:
  nn:20047969
• Citation:
  Matern Child Health J 2016 Jul; 20(7):1497-1505
• Contact Point Address:
  Hilda Razzaghi, National Center for Chronic Disease Prevention and Health, Pormotion, Centers for Disease Control and Prevention, (CDC), Mail-Stop F76, 1600 Clifton Road, Atlanta, GA 30333, USA
• Email:
  hir2@cdc.gov
• Federal Fiscal Year:
  2016
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Maternal and Child Health Journal
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9fe2e37849402132f8f5bf727cb36a11425367589a7eaf92a30ee743d7b36297cb392bac732e33b29d02978337444df71130315c3b81043be5d51a33049c3420
• Download URL:
  https://stacks.cdc.gov/view/cdc/202881/cdc_202881_DS1.pdf
• File Type:
  [PDF - 736.58 KB ]