A meta-analysis of studies investigating the effects of occupational lead exposure on thyroid hormones

Details

• Personal Author:
  Krieg EF Jr.
• Description:
  Introduction: Investigations of the effects of occupational exposure to lead on the concentrations of thyroid hormones in the blood have not produced consistent results. A meta-analysis was performed to assess the effect of occupational exposure to lead on thyroid hormone concentrations using the results from published studies. Methods: Group means from studies of the thyroid function of persons occupationally exposed to lead were used in a meta-analysis. Differences between the control and exposed groups, and the slopes between thyroid hormone concentrations and log10 blood lead concentrations or duration of exposure to lead were estimated using mixed models. The hormones analyzed were thyroid stimulating hormone, total and free thyroxine, and total and free triiodothyronine. Results: No differences in mean thyroid hormone concentrations were found between the exposed and control groups. No relationships were found between blood lead or the duration of exposure to lead and thyroid hormone concentrations. Conclusion: The results of the analysis do not provide evidence for an effect of occupational lead exposure on thyroid function in men. [Description provided by NIOSH]
• Subjects:
  Blood Endocrine System Environmental Exposure Lead Occupational Health Risk Assessment Risk Factors Safety
• Keywords:
  Author Keywords: Blood Lead Exposure Levels Hormones Lead Compounds Models Risk Factors Thyroid Gland Thyroid Gland Disorders Thyroid Stimulating Hormone Thyroxine Triiodothryonine

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• ISSN:
  0271-3586
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  59
• Issue:
  7
• NIOSHTIC Number:
  nn:20047913
• Citation:
  Am J Ind Med 2016 Jul; 59(7):583-590
• Contact Point Address:
  Edward F. Krieg, Jr., PhD, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, 1150 Tusculum Avenue, Cincinnati, Ohio 45226
• Email:
  erk3@cdc.gov
• CAS Registry Number:
  Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  2016
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Industrial Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:16c526bbf57c2377ee071026606f482077d43061e3949eb684d563453dc0924facbf3c1a496d672e68d0ba190a8d8a2f87a7994d7873d1f3f91960a05c6a3a9b
• Download URL:
  https://stacks.cdc.gov/view/cdc/202852/cdc_202852_DS1.pdf
• File Type:
  [PDF - 132.21 KB ]