Additive impairment of synaptic signaling in cultured cortical neurons by exogenously-applied oligomerized amyloid-beta and airborne nanoparticles generated during photocopying

Details

• Personal Author:
  Bello D ; Lee, Stephen A. ; Pal AK ; Shea TB ; Sohal IS ; Therrien MA
• Description:
  Photocopying in offices and printing centers releases nanoparticles that can reach the brain following inhalation. We examined whether subcytotoxic levels of airborne photocopy-emitted nanoparticles could potentiate perturbation of synaptic signaling in cultured neurons following exposure to amyloid-beta (A-beta). Signaling was only transiently inhibited by A-beta or nanoparticles individually, but remained statistically reduced in cultures receiving both after 24 h. In vitro and in vivo studies with copier emitted nanoparticles have consistently demonstrated inflammation, oxidative stress, and cytotoxicity. Since A-beta can accumulate years before cognitive decline, subcytotoxic levels of nanoparticles are one factor that could potentiate A-beta-induced impairment of synaptic activity during these early stages. [Description provided by NIOSH]
• Subjects:
  Cytotoxins Nervous System Occupational Health Particulate Matter Printing Respiratory System Safety
• Keywords:
  Author Keywords: Amyloid-beta Brain Damage Brain Disorders Brain Electrical Activity Brain Function Cell Signaling Cytotoxic Effects Cytotoxicity Inhalation Multi-electrode Arrays Nanoparticles Nanotechnology Neurotoxic Disorders Neurotoxicity Neurotoxicology Neurotransmitters Office Equipment Particulates Printers Printing Industry Printing Inks Printing Presses Signaling Synthetic Materials

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• ISSN:
  1387-2877
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  49-54
• Volume:
  47
• Issue:
  1
• NIOSHTIC Number:
  nn:20047861
• Citation:
  J Alzheimers Dis 2015 Jan; 47(1):49-54
• Contact Point Address:
  Thomas B. Shea, University of Massachusetts Lowell, 1 University Avenue, Lowell, MA 01821, USA
• Email:
  thomas_shea@uml.edu
• Federal Fiscal Year:
  2015
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Alzheimer's Disease
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:26ea94cdf02522448fed0b887fcff4155df08cbe3e952dcad0627c1ea322282c4d973152f67d8c6a3c5ccd4bee0d8908d155965fc457eef6b73d7f23d70972b3
• Download URL:
  https://stacks.cdc.gov/view/cdc/202819/cdc_202819_DS1.pdf
• File Type:
  [PDF - 317.36 KB ]