Occupational dust exposure and the risk of laryngeal cancer in Turkey

Details

• Personal Author:
  Akpinar-Elci, Muge ; Blair, Austin ; Dosemeci, Mustafa ; Elci, Omur Cinar
• Description:
  A hospital-based case-referent study was conducted to identify occupational risk factors for laryngeal cancer. In a previous report an association was found between laryngeal cancer and occupations with potential dust exposure; a job-exposure matrix was developed to aid further evaluation of laryngeal cancer risks from five occupational dust exposures. Among 7631 cancer cases from the Okmeydani Hospital, Istanbul, between 1979 and 1984, 958 larynx cancer cases were identified among men. After exclusions, 940 laryngeal cancer cases and 1519 referents were available. A standardized questionnaire was used to obtain basic information on the patients. Seven-digit standard occupational and industrial codes were created to classify the job and industrial titles. A job-exposure matrix was developed for occupational dusts, including silica, asbestos, wood, cotton, and grain, and age-, smoking-, and alcohol-adjusted odds ratios (OR) and 95% confidence intervals (95% CI) were calculated to evaluate risks of laryngeal cancer. An excess of laryngeal cancer occurred for workers potentially exposed to silica and cotton dust, particularly for supraglottic cancer (OR = 1.8, 95% CI = 1.3-2.3, for silica and OR = 1.6, 95% CI = 1.1-2.5, for cotton dust), and there was a significant dose-response relationship with silica exposure. No relationship was found between laryngeal cancer and asbestos, grain, or wood dust exposures. On the basis of these results it is concluded that laryngeal cancer, especially supraglottic tumors, is associated with silica and cotton dust exposures in Turkey. [Description provided by NIOSH]
• Subjects:
  Chemistry Dust Environmental Monitoring Hypersensitivity Neoplasms Occupational Exposure Occupational Health Respiratory Tract Diseases Safety Silicon Dioxide Solvents Workplace

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• Keywords:
  Author Keywords: Case-control Study Cancer Cancer-rates Case-referent Study Chemical-hypersensitivity Chemical-indicators Chemical-properties Cotton Dust-analysis Dust-exposure Dust-inhalation Dust-particles Dusts Epidemiology Exposure-assessment Industrial-dusts Laryngeal Cancer Larynx Larynx-cancer Occupational-exposure Occupational-health Occupational Dust Exposure Pulmonary-system-disorders Respiratory-system-disorders Risk Silica Turkey Vapors Work Work-areas Worker-health Workers

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• ISSN:
  0355-3140
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  278-284
• Volume:
  28
• Issue:
  4
• NIOSHTIC Number:
  nn:20047834
• Citation:
  Scand J Work Environ Health 2002 Aug; 28(4):278-284
• Contact Point Address:
  Dr Omur Cinar Elci, National Institute for Occupational Safety and Health, Division of Respiratory Diseases Studies, Field Studies Branch, MS2800, 1095 Willowdale Road, Morgantown, WV 26505, United States
• Email:
  oae3@cdc.gov
• CAS Registry Number:
  Asbestos (CAS RN 1332-21-4) ; Formaldehyde (CAS RN 50-00-0) ; Silica (CAS RN 7631-86-9)
• Federal Fiscal Year:
  2002
• Peer Reviewed:
  True
• Source Full Name:
  Scandinavian Journal of Work, Environment & Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6592c4ea90828d40c9f819c74d5b149782d115cb2f67555c75d5a8e7aed101f76b8a88aecba6c5e531a9863848397534f12913cb13f74ba14bbb8f6a0ce0178f
• Download URL:
  https://stacks.cdc.gov/view/cdc/202801/cdc_202801_DS1.pdf
• File Type:
  [PDF - 134.38 KB ]