Occupational Exposures and the Risk of Laryngeal Cancer in Turkey

Details

• Personal Author:
  Akpinar-Elci, Muge ; Blair, Austin ; Dosemeci, Mustafa ; Elci, Omur Cinar
• Description:
  Background. Laryngeal cancer is the second leading cancer among men in Turkey. A hospital based case-control study was conducted in Turkey to provide further information on occupational risk factors and laryngeal cancer. Methods. Among 7,631 cancer cases seen at an oncology treatment center of the Social Security Agency Hospital in Istanbul between 1979 - 84, 958 male larynx cancer cases were identified. Occupational history, tobacco and alcohol use, and demographic data were obtained from patients by a standardized questionnaire. Special seven-digit standard occupational and industrial codes were created to classify the job and industrial titles. To further evaluation, we also developed a job exposure matrix for occupational dusts including, asbestos, silica, cotton, grain, leather, and wood dusts, and for selected chemicals including, diesel exhaust, gasoline, PAH, formaldehyde, and solvents to analyze laryngeal cancer risks. After exclusions, 940 laryngeal cancer cases and 1519 controls were available for the study. We calculated age, smoking and alcohol adjusted odds ratios (OR) and 95% confidence intervals (CI) to evaluate risks of laryngeal cancer by occupational exposures. Results. Excesses of laryngeal cancer occurred among guards (OR, 95%CI) (1.5, 1.1-2.1), production supervisors (1.8, 1.1-3.1), drivers (1.7, 1.1-2.4), textile (1.9, 1.2-3.3), and construction workers (1.7, 1.2- 2.6) and workers in grain mills (3.1, 1.3-7.6), trade unions (3.6, 1.1-11.7) and in local government (4.7, 1.7-12.5). Supraglottic cancer was excessive among textile workers, construction workers and local government labors, all occupations with significant potential exposure to dust. Risks among general managers, electricians, pharmaceutical production, industrial machinery production, and retail services workers were lower. We observed an excess of laryngeal cancer among workers exposed to silica (1.4, 1.1-1.8), cotton dust (1.6, 1.1-2.5), diesel exhaust (1.5, 1.3-1.9), gasoline (1.6, 1.3-2.0), and PAH (1.3, 1.1-1.6), and there was a significant dose-response relationship with supraglottic cancers (p<0.00l). We did not find any relationship between laryngeal cancer and asbestos, grain, leather, wood dust, formaldehyde, and solvent exposures. Conclusion. Risk of laryngeal cancer was associated with several occupations and supraglottic larynx cancer appears to be more common among workers. Laryngeal cancer, especially supraglottic tumors, was associated with silica, cotton dust, diesel exhaust, gasoline, and PAH exposure in Turkey. [Description provided by NIOSH]
• Subjects:
  Chemistry Dust Environmental Monitoring Hypersensitivity Neoplasms Occupational Exposure Occupational Health Respiratory Tract Diseases Safety Solvents Workplace

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• Keywords:
  Cancer Cancer-rates Chemical-hypersensitivity Chemical-indicators Chemical-properties Dust-analysis Dust-exposure Dust-inhalation Dust-particles Dusts Exposure-assessment Industrial-dusts Larynx-cancer Occupational-exposure Occupational-health Pulmonary-system-disorders Respiratory-system-disorders Vapors Work-areas Worker-health Workers

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• ISSN:
  0025-7818
• Document Type:
  Text
• Genre:
  Abstract or Summary ; Proceedings
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  93
• Issue:
  5
• NIOSHTIC Number:
  nn:20033754
• Citation:
  Med Lav 2002 Sep; 93(5):385
• CAS Registry Number:
  Asbestos (CAS RN 1332-21-4) ; Formaldehyde (CAS RN 50-00-0) ; Silica (CAS RN 7631-86-9)
• Federal Fiscal Year:
  2002
• NORA Priority Area:
  Research Tools and Approaches: Risk Assessment Methods
• Peer Reviewed:
  False
• Source Full Name:
  La Medicina del Lavoro
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6fb74dbfe5ad0b8d14f0f46496f7d884ee7a24c7057543ce10298b79b3cc177b4992284b4385e20878f3013bd9074ca44190ceda343aa94e9ce6c25a5133d36e
• Download URL:
  https://stacks.cdc.gov/view/cdc/189208/cdc_189208_DS1.pdf
• File Type:
  [PDF - 279.12 KB ]