Insomnia in shift work disorder relates to occupational and neurophysiological impairment

Details

• Personal Author:
  Belcher R ; Gumenyuk V ; Roth T
• Description:
  Study Objectives: To determine whether occupational and neurophysiological decrements within shift work disorder (SWD) are differentially related to its two diagnostic symptoms, insomnia and excessive sleepiness. Methods: Thirty-four permanent night workers participated in an overnight lab protocol including a multiple sleep latency test (MSLT) and an event-related brain potential (ERP) task testing auditory target detection (P3a and P3b). At 16:00, each subject completed an Endicott Work Productivity Scale (EWPS), two Insomnia Severity Indices (ISI-Day, ISI-Night), and an Epworth Sleepiness Scale (ESS). Subjects were grouped by ISI and ESS scores into clinical phenotypes. This study compared EWPS and ERP results between alert insomniacs ("AI," reporting insomnia without sleepiness), sleepy insomniacs ("SI," reporting both insomnia and sleepiness), and controls. Results: The AI group was most impaired on the EWPS, signifi cantly more impaired than controls (25.8 +/- 14.8 vs. 12.3 +/- 9.4, p < 0.05). SI were not statistically different from controls (19.5 +/- 8.7 vs. 12.3 +/- 9.4, p > 0.05). Compared to controls, AI showed signifi cantly attenuated P3a response (Fcz, Czp, Cpz, mean difference [MD] 1.62-1.77, p < 0.05) and target-detection P3b response (Fcz, Czp, Cpz, MD 1.28-1.64, p < 0.05). P3b in SI was not different from controls (p > 0.10), and P3a was only different at one electrode site (Cpz, MD 1.43, p < 0.01). Neither the MSLT nor the ESS correlated with EWPS scores or ERP (P3a/P3b) amplitudes (p > 0.10). However, the mean of the ISI measurements correlated with the EWPS (r = 0.409, p < 0.01) and the attention-to-novelty P3a (r = -0.410, p < 0.01). Conclusions: Among shift work disorder patients, insomnia is linked to functional and cognitive impairments. Insomniacs with normal sleepiness showed more severe impairments than insomniacs who also reported excessive sleepiness. [Description provided by NIOSH]
• Subjects:
  Fatigue Nervous System Occupational Health Safety Shift Work Schedule Sleep Sleep Initiation And Maintenance Disorders Surveys And Questionnaires
• Keywords:
  Analytical-instruments Analytical-models Author Keywords: Insomnia Brain-function Circadian Phase Epworth Sleepiness Scale Event-related Brain Potentials Excessive Sleepiness Health-surveys Humans Insomnia Severity Index Multiple Sleep Latency Test Neurophysiological-effects Neurophysiology Physiological-fatigue Physiological-response Shift-work Shift-workers Shift Work Sleep-deprivation Sleep-disorders Work-intervals Work-performance Work Productivity

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• ISSN:
  1550-9389
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  457-465
• Volume:
  11
• Issue:
  4
• NIOSHTIC Number:
  nn:20047755
• Citation:
  J Clin Sleep Med 2015 Apr; 11(4):457-465
• Contact Point Address:
  Valentina Gumenyuk, PhD, MEG Neuroimaging Center, Meadowlands Hospital 55 Meadowlands Parkway, Secaucus, NJ 07094
• Email:
  vgumenyuk@meadowlandshospital.org
• Federal Fiscal Year:
  2015
• Performing Organization:
  Henry Ford Health System, Detroit, Michigan
• Peer Reviewed:
  True
• Start Date:
  20110901
• Source Full Name:
  Journal of Clinical Sleep Medicine
• End Date:
  20140831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7cd05bc7b2990af27dd821e211a795d49ccccda6ca0ee1509d1db56b079566ae2de52d0e13b8ea31c6eaa3aaa667e5fb16f1834a189a871596e532d0d5a51142
• Download URL:
  https://stacks.cdc.gov/view/cdc/202744/cdc_202744_DS1.pdf
• File Type:
  [PDF - 778.39 KB ]