Pooled analysis of C-reactive protein levels and mortality in prostate cancer patients

Details

• Personal Author:
  Beer TM ; Graff JN ; Liu B ; Sonpavde G ; Taioli E
• Description:
  INTRODUCTION: Previous studies have reported that higher C-reactive protein (CRP) levels are significantly associated with worse outcome in prostate cancer patients. The size of each individual study was not large enough to allow sufficient statistical power to draw conclusions. We conducted a pooled analysis of individual data of published studies to evaluate the association between increased CRP level and risk of death in prostate cancer, and to find the best CRP cutoff that could predict mortality. MATERIALS AND METHODS: Original research studies on prostate cancer survival and CRP levels were identified (n = 6). Corresponding authors were contacted and invited to share individual data. Two data sets were received (235 patients). The combined hazard ratio (HR) was calculated and adjusted for age, prostate-specific antigen, hemoglobin, and alkaline phosphatase. The best cutoff of CRP was explored using X-title software version 3.6.1. RESULTS: High CRP level was statistically significantly associated with mortality (meta-HR, 1.83 [95% confidence interval (CI), 1.51-2.21]), without evidence of heterogeneity among studies. At pooled analysis, adjusted pooled HR for CRP < 5 versus = 5 mg/L was 1.44 (95% CI, 1.02-20.4). The best CRP cutoff was 12 mg/L: the adjusted HRpooled for CRP < 12 versus = 12 mg/L was 1.53 (95% CI, 1.01-2.32). CONCLUSION: Increased CRP levels are associated with overall survival in prostate cancer patients. Because CRP is an affordable and readily available assay, it might hold promise in improving prognostication and potentially to predict the activity of specific therapeutic agents. [Description provided by NIOSH]
• Subjects:
  Biomarkers Diagnosis Epidemiology Neoplasms Occupational Health Safety
• Keywords:
  Author Keywords: Epidemiological Methods Cancer Diagnostic Techniques Diagnostic Tests Outcome Prognostic Markers Prostate Cancer Statistical Analysis Systemic Inflammation Urogenital System Disorders Urological Cancer

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• ISSN:
  1558-7673
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Alabama ; New York ; Oregon ; OSHA Region 10 ; OSHA Region 2 ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  13
• Issue:
  4
• NIOSHTIC Number:
  nn:20047744
• Citation:
  Clin Genitourin Cancer 2015 Aug; 13(4):e217-e221
• Contact Point Address:
  Emanuela Taioli, MD, PhD, Hofstra North Shore-LIJ School of Medicine and North Shore/LIJ Health System, The Feinstein Institute for Medical Research, 175 Community Dr, Rm 203, Manhasset, NY 11021
• Email:
  taiolema@gmail.com
• Federal Fiscal Year:
  2015
• Performing Organization:
  Icahn School of Medicine at Mount Sinai, New York
• Peer Reviewed:
  False
• Start Date:
  20130701
• Source Full Name:
  Clinical Genitourinary Cancer
• End Date:
  20170630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3781c12d985643490e1d8f0a0debec18351efbc7d187a67e31998ad786dc4b92811bbd92655c676b1eecbf45a1e44fa3a157cef5b76f3b0b84f2ae47eb172a5f
• Download URL:
  https://stacks.cdc.gov/view/cdc/202736/cdc_202736_DS1.pdf
• File Type:
  [PDF - 294.68 KB ]