The influence of inhaled multi-walled carbon nanotubes on autonomic nervous system

Details

• Personal Author:
  Castranova, Vincent ; Kan H ; Kashon M ; McKinney W ; Pan D ; Salmen R ; Zheng W
• Description:
  Heart rate and cardiovascular function are regulated by the autonomic nervous system. Heart rate variability (HRV) as a marker reflects the activity of autonomic nervous system. The prognostic significance of HRV in cardiovascular disease has been reported in clinical and epidemiological studies. The present study focused on the influence of inhaled multiwalled carbon nanotubes (MWCNTs) on autonomic nervous system by HRV analysis. Methods: Male Sprague-Dawley rats were pre-implanted with telemetry device and kept in the individual cages for recovery. At week four after device implantation, rats were exposed to MWCNTs for 5h at a concentration of 5 mg/m3. The real-time EKGs were recorded by a telemetry system at pre-exposure, during exposure, 1 day and 7 days post-exposure. HRV was measured by root mean square of successive differences (RMSSD); the standard deviation of RR interval (SDNN); the proportion of NN5 or NN10 divided by total number of NNs (pNN5 or pNN10); low frequency (LF) and high frequency (HF). Results: Exposure to MWCNTs significantly increased the percentage of differences between adjacent R-R intervals over 5 ms (pNN5) and 10 ms (pNN10) (p<0.01), the root mean square of the successive differences (RMSSD) (p<0.01), the power of low frequency (LF) (P<0.05) and high frequency (HF) (p<0.01). Conclusions: Inhalation of MWCNTs significantly altered the performance of autonomic nervous system dominated by an increased activity of the parasympathetic nervous system during the exposure. Such a transient alteration in autonomic nervous performance may raise the risk of cardiovascular events in people with pre-existing cardiovascular conditions. [Description provided by NIOSH]
• Subjects:
  Biomarkers Cardiovascular System Laboratories Occupational Health Respiratory System Safety Toxicology
• Keywords:
  Autonomic Nervous System Cardiovascular Function Heart Rate Inhalation Laboratory Animals Laboratory Testing Multi-walled Carbon Nanotubes MWCNT Nanotechnology Nanotubes Nervous System Nervous System Function Parasympathetic Nervous System

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• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  Louisiana ; OSHA Region 3 ; OSHA Region 6 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  150
• Issue:
  1
• NIOSHTIC Number:
  nn:20047724
• Citation:
  Toxicologist 2016 Mar; 150(1):430
• Federal Fiscal Year:
  2016
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 55th Annual Meeting and ToxExpo, March 13-17, 2016, New Orleans, Louisiana
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4b7ffb9810c66fed8fdc2e0def72d7740b04f823d9888feb2e86fc4cf555c33b3079ff618abd357a6ddf72e1b6c5bb514632d6ae65e6f7724fb55c999595ba85
• Download URL:
  https://stacks.cdc.gov/view/cdc/202721/cdc_202721_DS1.pdf
• File Type:
  [PDF - 442.38 KB ]