The association of urine arsenic with prevalent and incident chronic kidney disease: evidence from the Strong Heart Study

Details

• Personal Author:
  Bandeen-Roche K ; Francesconi KA ; Goessler W ; Guallar E ; Howard BV ; Navas-Acien A ; Silbergeld EK ; Umans JG ; Weaver VM ; Yeh F ; Zheng LY
• Description:
  BACKGROUND: Few studies have evaluated associations between low to moderate arsenic levels and chronic kidney disease (CKD). The objective was to evaluate the associations of inorganic arsenic exposure with prevalent and incident CKD in American Indian adults. METHODS: We evaluated the associations of inorganic arsenic exposure with CKD in American Indians who participated in the Strong Heart Study in 3,851 adults ages 45-74 years in a cross-sectional analysis, and 3,119 adults with follow-up data in a prospective analysis. Inorganic arsenic, monomethylarsonate, and dimethylarsinate were measured in urine at baseline. CKD was defined as estimated glomerular filtration rate <60ml/min/1.73 m2, kidney transplant or dialysis. RESULTS: CKD prevalence was 10.3%. The median (IQR) concentration of inorganic plus methylated arsenic species (total arsenic) in urine was 9.7 (5.8, 15.7) µg/L. The adjusted odds ratio (OR; 95% confidence interval) of prevalent CKD for an interquartile range in total arsenic was 0.7 (0.6, 0.8), mostly due to an inverse association with inorganic arsenic (OR: 0.4 [0.3, 0.4]). Monomethylarsonate and dimethylarsinate were positively associated with prevalent CKD after adjustment for inorganic arsenic (OR: 3.8 and 1.8). The adjusted hazard ratio of incident CKD for an IQR in sum of inorganic and methylated arsenic was 1.2 (1.03, 1.41). The corresponding HRs for inorganic arsenic, monomethylarsonate, and dimethylarsinate were 1.0 (0.9, 1.2), 1.2 (1.00, 1.3), and 1.2 (1.0, 1.4). CONCLUSIONS: The inverse association of urine inorganic arsenic with prevalent CKD suggests that kidney disease affects excretion of inorganic arsenic. Arsenic species were positively associated with incident CKD. Studies with repeated measures are needed to further characterize the relation between arsenic and kidney disease development. [Description provided by NIOSH]
• Subjects:
  Arsenic Chronic Disease Epidemiology Inorganic Chemicals Occupational Health Safety Urine
• Keywords:
  Chronic Diseases Kidney Disorders Kidneys Urinalysis
• ISSN:
  1044-3983
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; Oklahoma ; OSHA Region 3 ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  26
• Issue:
  4
• NIOSHTIC Number:
  nn:20047594
• Citation:
  Epidemiology 2015 Jul; 26(4):601-612
• Contact Point Address:
  Laura Y. Zheng, Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Room W7513, Baltimore, MD 21205
• Email:
  lzheng15@jhu.edu
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2)
• Federal Fiscal Year:
  2015
• Performing Organization:
  Johns Hopkins University
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Epidemiology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9c275616205ef8f409a9ada335ab1f88d6c7fbc93cabce3dba4c68706d52f2bf31030ff5ef197beff47fcd6ccebea2f07b220f230ea1648377a09305cc9631ab
• Download URL:
  https://stacks.cdc.gov/view/cdc/202609/cdc_202609_DS1.pdf
• File Type:
  [PDF - 497.79 KB ]