Cancer incidence among Minnesota taconite mining industry workers

Details

• Personal Author:
  Alexander BH ; Allen EM ; MacLehose RF ; Mandel JH ; Nelson HH ; Ramachandran G
• Description:
  PURPOSE: To evaluate cancer incidence among Minnesota taconite mining workers. METHODS: We evaluated cancer incidence between 1988 and 2010 in a cohort of 40,720 Minnesota taconite mining workers used between 1937 and 1983. Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were estimated by comparing numbers of incident cancers with frequencies in the Minnesota Cancer Surveillance System. SIRs for lung cancer by histologic subtypes were also estimated. We adjusted for out-of-state migration and conducted a probabilistic bias analysis for smoking-related cancers. RESULTS: A total of 5700 cancers were identified, including 51 mesotheliomas and 973 lung cancers. The SIRs for lung cancer and mesothelioma were 1.3 (95% CI = 1.2-1.4) and 2.4 (95% CI = 1.8-3.2), respectively. Stomach, laryngeal, and bladder cancers were also elevated. However, adjusting for potential confounding by smoking attenuated the estimates for lung (SIR = 1.1, 95% CI = 1.0-1.3), laryngeal (SIR = 1.2, 95% CI = 0.8-1.6), oral (SIR = 0.9, 95% CI = 0.7-1.2), and bladder cancers (SIR = 1.0, 95% CI = 0.8-1.1). CONCLUSIONS: Taconite workers may have an increased risk for certain cancers. Lifestyle and work-related factors may play a role in elevated morbidity. The extent to which mining-related exposures contribute to disease burden is being investigated. [Description provided by NIOSH]
• Subjects:
  Digestive System Digestive System Diseases Epidemiology Lung Lung Diseases Mining Neoplasms Occupational Exposure Occupational Health Respiratory System Respiratory Tract Diseases Safety Smoke Smokers Tobacco Products

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• Keywords:
  Author Keywords: Epidemiology Bladder Cancer Bladder Disease Bladder Disorders Cancer Cigarette Smoke Cigarette Smoking Gastrointestinal System Disorders Larynx Cancer Lung Cancer Mesothelioma Miners Mine Workers Mining Industry Occupational Exposure Pulmonary System Disorders Respiratory System Disorders Smoking Statistical Analysis Stomach Cancer Stomach Disorders Taconite Tobacco Smoke Urogenital System Disorders

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• ISSN:
  1047-2797
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Minnesota ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  25
• Issue:
  11
• NIOSHTIC Number:
  nn:20047590
• Citation:
  Ann Epidemiol 2015 Nov; 25(11):811-815.e1
• Contact Point Address:
  Elizabeth M. Allen PhD, Department of Family Medicine and Community Health, University of Minnesota, 717 Delaware St. SE, Suite 166, Minneapolis, MN 55455
• Email:
  gasto020@umn.edu
• CAS Registry Number:
  Taconite (CAS RN 12249-26-2)
• Federal Fiscal Year:
  2016
• Performing Organization:
  University of Minnesota Twin Cities
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Annals of Epidemiology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c82bcd8295459eb4f4f70699860e41758f4ff50f9aefe282d2f8927c94081f3f2bde1bca572a0f35969889287a064b80ca3465e4dda278f562486263525549a7
• Download URL:
  https://stacks.cdc.gov/view/cdc/202605/cdc_202605_DS1.pdf
• File Type:
  [PDF - 227.92 KB ]