Biomarkers of World Trade Center particulate matter exposure: physiology of distal airway and blood biomarkers that predict FEV1 decline

Details

• Personal Author:
  Berger KI ; Caraher E ; Kwon S ; Nolan A ; Prezant DJ ; Reibman J ; Rom, William N. ; Weiden MD
• Description:
  Biomarkers can be important predictors of disease severity and progression. The intense exposure to particulates and other toxins from the destruction of the World Trade Center (WTC) overwhelmed the lung's normal protective barriers. The Fire Department of New York (FDNY) cohort not only had baseline pre-exposure lung function measures but also had serum samples banked soon after their WTC exposure. This well-phenotyped group of highly exposed first responders is an ideal cohort for biomarker discovery and eventual validation. Disease progression was heterogeneous in this group in that some individuals subsequently developed abnormal lung function while others recovered. Airflow obstruction predominated in WTC-exposed patients who were symptomatic. Multiple independent disease pathways may cause this abnormal FEV1 after irritant exposure. WTC exposure activates one or more of these pathways causing abnormal FEV1 in an individual. Our hypothesis was that serum biomarkers expressed within 6 months after WTC exposure reflect active disease pathways and predict subsequent development or protection from abnormal FEV1 below the lower limit of normal known as WTC-Lung Injury (WTC-LI). We utilized a nested case-cohort control design of previously healthy never smokers who sought subspecialty pulmonary evaluation to explore predictive biomarkers of WTC-LI. We have identified biomarkers of inflammation, metabolic derangement, protease/antiprotease balance, and vascular injury expressed in serum within 6 months of WTC exposure that were predictive of their FEV1 up to 7 years after their WTC exposure. Predicting future risk of airway injury after particulate exposures can focus monitoring and early treatment on a subset of patients in greatest need of these services. [Description provided by NIOSH]
• Subjects:
  Biomarkers Emergency Responders Firefighters Lung Lung Diseases Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Analytical-processes Author Keywords: World Trade Center Emergency-responders Fire-fighters Lung-disease Lung-disorders Lung-function Lung Injury Obstructive Airway Disease Particulate-dust Particulates Predictive Biomarkers Pulmonary-function Pulmonary-system-disorders Respiratory-system-disorders Statistical-analysis

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• ISSN:
  1069-3424
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Contract
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  323-333
• Volume:
  36
• Issue:
  3
• NIOSHTIC Number:
  nn:20047476
• Citation:
  Semin Respir Crit Care Med 2015 Jun; 36(3):323-333
• Contact Point Address:
  Anna Nolan, MD, MS, Division of Pulmonary, Critical Care and Sleep, NYU School of Medicine, 462 1st Avenue, New Bellevue, 7N Room 24, New York, NY 10016
• Email:
  anna.nolan@med.nyu.edu
• Federal Fiscal Year:
  2015
• Performing Organization:
  New York City Fire Department
• Peer Reviewed:
  True
• Start Date:
  20040701
• Source Full Name:
  Seminars in Respiratory and Critical Care Medicine
• End Date:
  20110630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4bed48ca9b0cd1458200e6835a66d806999f5f1ded9cb18f1fae2a098a3e32121b9d1673e57ebce8f5244428c02230036cc66953355c0b789a187a1154e24501
• Download URL:
  https://stacks.cdc.gov/view/cdc/202532/cdc_202532_DS1.pdf
• File Type:
  [PDF - 320.25 KB ]