The influence of inhaled multi-walled carbon nanotubes on the autonomic nervous system

Details

• Personal Author:
  Castranova, Vincent ; Kan H ; Kashon M ; McKinney W ; Salmen R ; Zheng W
• Description:
  Background: Heart rate and cardiovascular function are regulated by the autonomic nervous system. Heart rate variability (HRV) as a marker reflects the activity of autonomic nervous system. The prognostic significance of HRV in cardiovascular disease has been reported in clinical and epidemiological studies. The present study focused on the influence of inhaled multi-walled carbon nanotubes (MWCNTs) on autonomic nervous system by HRV analysis. Methods: Male Sprague-Dawley rats were pre-implanted with a telemetry device and kept in the individual cages for recovery. At week four after device implantation, rats were exposed to MWCNTs for 5 h at a concentration of 5 mg/m3. The real-time EKGs were recorded by a telemetry system at pre-exposure, during exposure, 1 day and 7 days post-exposure. HRV was measured by root mean square of successive differences (RMSSD); the standard deviation of inter-beat (RR) interval (SDNN); the percentage of successive RR interval differences greater than 5 ms (pNN5) and 10 ms (pNN10); low frequency (LF) and high frequency (HF). Results: Exposure to MWCNTs increased the percentage of differences between adjacent R-R intervals over 10 ms (pNN10) (p < 0.01), RMSSD (p < 0.01), LF (p < 0.05) and HF (p < 0.01). Conclusions: Inhalation of MWCNTs significantly alters the balance between sympathetic and parasympathetic nervous system. Whether such transient alterations in autonomic nervous performance would alter cardiovascular function and raise the risk of cardiovascular events in people with pre-existing cardiovascular conditions warrants further study. [Description provided by NIOSH]
• Subjects:
  Cardiovascular System Electrocardiography Environmental Monitoring Laboratories Nervous System Occupational Health Respiratory System Safety
• Keywords:
  Author Keywords: Inhalation Autonomic-nervous-system Autonomic Nervous System Biological-effects Carbon-compounds Cardiovascular-function Exposure-assessment Exposure-levels Heart-rate Heart Rate Variability Laboratory-animals Laboratory-techniques Laboratory-testing Multi-walled Carbon Nanotubes Nanotechnology Nervous-system Nervous-system-function

  More +
• ISSN:
  1743-8977
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  8
• Volume:
  13
• NIOSHTIC Number:
  nn:20047441
• Citation:
  Part Fibre Toxicol 2016 Feb; 13:8
• Contact Point Address:
  W. Zheng, 1Health Effects Laboratory Division, Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
• Email:
  hvn4@cdc.gov
• CAS Registry Number:
  Carbon (CAS RN 7440-44-0)
• Federal Fiscal Year:
  2016
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Particle and Fibre Toxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0636d1198db7c5aa298534abde27116805c751a78021254f97c54eb94fe9d8ea26a3b93109450d9e342e67fb75058144a82443e634a908ee19744372ba6c467e
• Download URL:
  https://stacks.cdc.gov/view/cdc/202501/cdc_202501_DS1.pdf
• File Type:
  [PDF - 1.11 MB ]