Disrupted sleep: from molecules to cognition

Details

• Personal Author:
  Chee MWL ; Cirelli C ; Dijk D-J ; Schwartz S ; Van Cauter E ; Van Someren EJW
• Description:
  Although the functions of sleep remain to be fully elucidated, it is clear that there are far-reaching effects of its disruption, whether by curtailment for a single night, by a few hours each night over a long period, or by disruption in sleep continuity. Epidemiological and experimental studies of these different forms of sleep disruption show deranged physiology from subcellular levels to complex affective behavior. In keeping with the multifaceted influence of sleep on health and well-being, we illustrate how the duration of sleep, its timing, and continuity can affect cellular ultrastructure, gene expression, metabolic and hormone regulation, mood, and vigilance. Recent brain imaging studies provide some clues on mechanisms underlying the most common cause of disrupted sleep (insomnia). These insights should ultimately result in adequate interventions to prevent and treat sleep disruption because of their high relevance to our most prevalent health problems. SIGNIFICANCE STATEMENT: Disruption of the duration, timing, and continuity of sleep affects cellular ultrastructure, gene expression, appetite regulation, hormone production, vigilance, and reward functions. [Description provided by NIOSH]
• Subjects:
  Behavior Endocrine System Energy Metabolism Epidemiology Genetics Mental Health Nervous System Occupational Health Pathology Safety Sleep Sleep Initiation And Maintenance Disorders

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• Keywords:
  Author Keywords: Sleep Disruption Brain-function Cellular-reactions Cellular-structures Cellular Ultrastructure Gene Expression Genes Hormone-activity Hormones Humans Insomnia Mental-processes Metabolic-activation Metabolism Mood Physiological-effects Physiopathology Sleep-deprivation Sleep-disorders Subcellular-structure

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• ISSN:
  0270-6474
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; OSHA Region 5 ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  35
• Issue:
  41
• NIOSHTIC Number:
  nn:20047330
• Citation:
  J Neurosci 2015 Oct; 35(41):13889-13895
• Contact Point Address:
  Eus J.W. Van Someren, Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands
• Email:
  e.van.someren@nin.knaw.nl
• Federal Fiscal Year:
  2016
• Performing Organization:
  University of Chicago
• Peer Reviewed:
  True
• Start Date:
  20090901
• Source Full Name:
  The Journal of Neuroscience
• End Date:
  20150831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c0b2ebe7e2398f16f508f6626fc329983cd1385d62d5846a1e8968e91042117e7e00a5a1607a675cafbe9a7bb8a5c9baef43eec42952323715efe4406d6c21b5
• Download URL:
  https://stacks.cdc.gov/view/cdc/202440/cdc_202440_DS1.pdf
• File Type:
  [PDF - 158.52 KB ]