Evaluating endocrine disruption activity of deposits on firefighting gear using a sensitive and high throughput screening method

Details

• Personal Author:
  Alexander B ; Baxter S ; Leung Y-K ; Stevenson M
• Description:
  Objective: Adverse health outcomes related to exposure to endocrine disrupting chemicals, including increased incidences of coronary heart disease, prostate and testicular cancers, and congenital disabilities, have been reported in firefighters or their offspring. We, therefore, measured the estrogenic and antiestrogenic activity of extracts of used firefighter gear to assess exposure to these agents. Methods: Extracts and known chemical contaminants were examined for estrogenicity and antiestrogenicity in yeast cells expressing the estrogen receptor. Results: Most extracts of used gear and phthalate diesters detectable on this gear displayed strong antiestrogenic effects. Notably, new glove and hood extracts showed significant estrogenic activity. Conclusions: Overall, our data suggest that firefighters are exposed to both estrogenic and antiestrogenic agents, possibly phthalates that may lead to health risks observed in this occupation as a result of perturbation of hormone homeostasis. [Description provided by NIOSH]
• Subjects:
  Cardiovascular System Chemistry Endocrine System Endocrine System Diseases Estrogens Firefighters Men Neoplasms Occupational Health Personal Protective Equipment Risk Assessment Risk Factors Safety Women

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• Keywords:
  Cancer Chemical-properties Chemical-reactions Children Endocrine-function Endocrine-system Endocrine-system-disorders Estrogenic-hormones Exposure-levels Fire-fighters Heart Heart-rate Humans Personal-protective-equipment Risk-factors

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• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  57
• Issue:
  12
• NIOSHTIC Number:
  nn:20047106
• Citation:
  J Occup Environ Med 2015 Dec; 57(12):e153-e157
• Contact Point Address:
  Yuet-Kin Leung, PhD, Cancer Institute, University of Cincinnati College of Medicine, 160 Penzeca Way, Kettering Lab Complex Rm 331, Cincinnati, OH 45267
• Email:
  Ricky.Leung@uc.edu
• Federal Fiscal Year:
  2016
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:19883960d18787f701738abac03af22e2942447ef3ebfe3357953235993a9c4dc77415e90fdc9b5684d8cab40ea04754683ee8fac74bdc335152f46e105ccd34
• Download URL:
  https://stacks.cdc.gov/view/cdc/202299/cdc_202299_DS1.pdf
• File Type:
  [PDF - 262.68 KB ]