N-acetyltransferase 2 genotypes are associated with diisocyanate-induced asthma

Details

• Personal Author:
  Bernstein DI ; Boulet L-P ; Cartier A ; Cruz M-J ; Gautrin D ; Johnson VJ ; Kissling GE ; Lummus ZL ; Luster MI ; Munoz X ; Quirce S ; Sastre J ; Tarlo SM ; Yucesoy, Berran
• Description:
  Objective: To investigate whether genetic variants of N-acetyltransferase (NAT) genes are associated with diisocyanate asthma (DA). Methods: The study population consisted of 354 diisocyanate-exposed workers. Genotyping was performed using a 5'-nuclease polymerase chain reaction assay. Results: The NAT2 rs2410556 and NAT2 rs4271002 variants were significantly associated with DA in the univariate analysis. In the first logistic regression model comparing DA+ and asymptomatic worker groups, the rs2410556 (P = 0.004) and rs4271002 (P < 0.001) single nucleotide polymorphisms and the genotype combination, NAT2 rs4271002*NAT1 rs11777998, showed associations with DA risk (P = 0.014). In the second model comparing DA+ and DA- groups, NAT2 rs4271002 variant and the combined genotype, NAT1 rs8190845*NAT2 rs13277605, were significantly associated with DA risk (P = 0.022, P = 0.036, respectively). Conclusions: These findings suggest that variations in the NAT2 gene and their interactions contribute to DA susceptibility. [Description provided by NIOSH]
• Subjects:
  Antigens Asthma Asthma, Occupational Chemistry Genetics Occupational Health Risk Assessment Risk Factors Safety Workplace
• Keywords:
  Author Keywords: Diisocyanate Bronchial-asthma Chemical-composition Chemical-properties Exposure-levels Genes Genetic Genotype Leukocytes Occupational Asthma Risk-factors Work-environment Workers

  More +
• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  North Carolina ; Ohio ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  57
• Issue:
  12
• NIOSHTIC Number:
  nn:20047104
• Citation:
  J Occup Environ Med 2015 Dec; 57(12):1331-1336
• Contact Point Address:
  Berran Yucesoy, PhD, Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, OH 45267
• Email:
  berranyucesoy@gmail.com
• Federal Fiscal Year:
  2016
• NORA Priority Area:
  Construction ; Manufacturing
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20060901
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20180831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:96fc9255905a8e568906f5af21066dfbf06ca6425b116de10043bfe7eac4d9dc1d8cabad8eb8af2df1dfae23d8b780618be309d7555f5475bf744a4426155d35
• Download URL:
  https://stacks.cdc.gov/view/cdc/202298/cdc_202298_DS1.pdf
• File Type:
  [PDF - 170.49 KB ]