Genetics of occupational asthma

Details

• Personal Author:
  Bernstein DL
• Description:
  Purpose of review: To discuss gene association studies conducted in workers diagnosed with occupational asthma. Recent findings: Human leukocyte antigen studies conducted in European workers have defined major histocompatibility complex class II alleles and haplotypes associated with diisocyanate asthma. Recently, certain glutathione S-transferase genotypes (e.g. the GSTM1 null genotype) and N-acetyltransferase genotypes associated with slow acetylation phenotypes have been reported to be associated with diisocyanate asthma. Genotype combinations of IL-4 receptor-a and CD14 single nucleotide polymorphisms (SNPs) were significantly associated with diisocyanate asthma, but only in workers exposed to hexamethylene diisocyanate. A recent genome-wide association study (GWAS) conducted in Korea identified several SNPs of the a-T-catenin gene that were significantly associated with diisocyanate asthma. Summary: Although candidate gene association studies have yet to identify reliable predictors of occupational asthma, future investigations including GWAS studies may identify highrisk genotypes allowing identification of workers at risk. [Description provided by NIOSH]
• Subjects:
  Antigens Asthma Asthma, Occupational Chemistry Genetics Occupational Health Risk Assessment Risk Factors Safety Workplace
• Keywords:
  Author Keywords: Diisocyanate Bronchial-asthma Chemical-composition Chemical-properties Exposure-levels Genes Genetic Genotype Leukocytes Occupational Asthma Risk-factors Work-environment Workers

  More +
• ISSN:
  1528-4050
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  86-89
• Volume:
  11
• Issue:
  2
• NIOSHTIC Number:
  nn:20046679
• Citation:
  Curr Opin Allergy Clin Immunol 2011 Apr; 11(2):86-89
• Contact Point Address:
  David I. Bernstein, MD, Professor of Medicine and Environmental Health, Division of Immunology, Allergy and Rheumatology, Department of Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way ML 563, Cincinnati, OH 45267
• Email:
  bernstdd@ucmail.uc.edu
• Federal Fiscal Year:
  2011
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20060901
• Source Full Name:
  Current Opinion in Allergy and Clinical Immunology
• End Date:
  20180831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9723eee0d51a9ef120574063ca2fca92863aa04213d725086d080706a0ce51a880bc852fdc0dfab3ce3b2c01afddefc0c49d7678cb0d6dde4bca6cd2b55bff22
• Download URL:
  https://stacks.cdc.gov/view/cdc/202031/cdc_202031_DS1.pdf
• File Type:
  [PDF - 131.96 KB ]