Inhalation of multi-walled carbon nanotubes affects lung resistance and compliance and evokes airway hyperreactivity to methacholine in rats

Details

• Personal Author:
  Endo M ; Fedan, Jeffery S. ; Frazer D ; McKinney W ; Porter, Dale ; Thompson J ; Tsuruoka S
• Description:
  The incorporation of carbon nanotubes into new materials has raised concerns about their potential hazards to workers exposed during manufacturing. In animals, following pharyngeal aspiration, i.t. instillation and inhalation exposures to MWCNT, airway inflammation and lung fibrosis have been reported. However, the effects of inhalation of MWCNT on pulmonary function and reactivity to inhaled methacholine (MCh), a bronchoconstrictor, have not been studied. Therefore, we investigated whether inhaled MWCNT affect lung resistance (RL) and dynamic compliance (CDyn), and/or reactivity to inhaled MCh aerosol. Male rats were exposed for 6 h to filtered air or 5 mg/m3 of aerosolized MWCNT (MWNT-7; Hodogaya Chemical Co.; 20 - 50 walls; median length, 3.86 µm; mean width, 49 nm; mass median aerodynamic diameter, 1.5 um; particle count aerodynamic diameter mode, approximately 0.4 µm). Basal RL and CDyn were measured 18 h and 7 d after the end of exposure, and responses to increasing concentrations of MCh were obtained. Eighteen h after exposure basal RL was increased and basal CDyn was decreased; 7 d after exposure basal RL and CDyn were not changed. Reactivity to MCh (RL) was increased and CDyn responses were decreased at 18 h but not 7 d after exposure. The results indicate that lung function and airway reactivity changes occur acutely, but that these changes subside over time following a single MWCNT inhalation exposure. [Description provided by NIOSH]
• Subjects:
  Aerosols Animals Fibrosis Laboratories Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Workplace

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• Keywords:
  Carbon-compounds Exposure-levels Hazards Laboratory-animals Lung-disease Lung-fibrosis Nanotechnology Pulmonary-function Pulmonary-system Pulmonary-system-disorders Respiratory-system-disorders Risk-factors Work-environment Workers

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• ISSN:
  0892-6638
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  28
• NIOSHTIC Number:
  nn:20046919
• Citation:
  FASEB J 2014 Apr; 28(Suppl 1):660.1
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  The FASEB Journal
• Supplement:
  1
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e1ef1b6868eb63e1c3933284e8b7f8ea1e077170923be589687b94c7753f9c86f401ef834096158787e81093d20bc1e4f2b958d059b72b6d0533926c26e55f35
• Download URL:
  https://stacks.cdc.gov/view/cdc/202183/cdc_202183_DS1.pdf
• File Type:
  [PDF - 56.21 KB ]