Changes in specific IgE and IgG and monocyte chemoattractant protein-1 in workers with occupational asthma caused by diisocyanates and removed from exposure

Details

• Personal Author:
  Bernstein DI ; L'Archeveque J ; Lummus Z ; Malo J-L
• Description:
  Workers with occupational asthma (OA) generally show improvement in symptoms and lung function after being removed from exposure, although the majority are left with permanent asthma and airway inflammation even several years after diagnosis. Few studies have examined changes in specific antibodies to agents causing OA after removal from exposure. The mean half-life of specific IgE antibodies to snow crab was 20 months and, to tetrachlorophthalic anhydride, 1 year. Tee et al reported that the half-life for specific IgE reactive with diisocyanate human serum albumin (HSA) measured by RAST ranged from 5 to 7 months. Park et al found that the mean half-life to isocyanates was 3.9 years in the case of specific IgE and 4.5 years for specific IgG. Levels of diisocyanate antigenstimulated monocyte chemoattractant protein-1 (MCP-1) are more satisfactorily associated with OA to isocyanates than specific IgE and IgG. The aims of this study are therefore to describe the changes in immunological reactivity (specific IgE, specific IgG, MCP-1) in workers previously assessed at the time the diagnosis of diisocyanate-induced OA was made and who left further exposure to the agent after the diagnosis. We also compared the functional and inflammatory changes with immunological changes in the same workers. [Description provided by NIOSH]
• Subjects:
  Antibodies Asthma Asthma, Occupational Genetics Lung Lung Diseases Men Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Women Workplace

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• Keywords:
  Antibody-response Bronchial-asthma Cell-function Exposure-levels Genes Humans Pulmonary-disorders Pulmonary-function Pulmonary-system Pulmonary-system-disorders Respiratory-system-disorders Risk-factors Work-environment Workers

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• ISSN:
  0091-6749
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  118
• Issue:
  2
• NIOSHTIC Number:
  nn:20046678
• Citation:
  J Allergy Clin Immunol 2006 Aug; 118(2):530-533
• Contact Point Address:
  Dr. David Bernstein, Professor, University of Cincinnati College of Medicine, Internal Medicine, Department of Allergy and Immunology, 3255 Eden Ave, Cincinnati OH 45267-0563
• Federal Fiscal Year:
  2006
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  False
• Start Date:
  20060901
• Source Full Name:
  Journal of Allergy and Clinical Immunology
• End Date:
  20180831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:74dc83b65360e987746374da549b0c13f664e1bdadea11efd157a0dd2f9830363ec072b0535d7ff72c76921a2c80043dc921a161bdebd41fd456e14e99017865
• Download URL:
  https://stacks.cdc.gov/view/cdc/202030/cdc_202030_DS1.pdf
• File Type:
  [PDF - 95.45 KB ]