Maternal occupational exposure to polycyclic aromatic hydrocarbons and craniosynostosis among offspring in the National Birth Defects Prevention Study

Details

• Personal Author:
  Agopian AJ ; Langlois PH ; Lawson, Christina C. ; Lupo PJ ; O'Brien JL ; Rocheleau CM ; Romitti PA ; Scheuerle A ; Synmanski E ; Waters MA
• Corporate Authors:
  National Birth Defects Prevention Network
• Description:
  Background: Evidence in animal models and humans suggests that exposure to polycyclic aromatic hydrocarbons (PAHs) may lead to birth defects. To our knowledge, this relationship has not been evaluated for craniosynostosis, a birth defect characterized by the premature closure of sutures in the skull. We conducted a case-control study to examine associations between maternal occupational exposure to PAHs and craniosynostosis. Methods: We used data from craniosynostosis cases and control infants in the National Birth Defects Prevention Study (NBDPS) with estimated delivery dates from 1997 to 2002. Industrial hygienists reviewed occupational data from the computer-assisted telephone interview and assigned a yes/no rating of probable occupational PAH exposure for each job from 1 month before conception through delivery. We used logistic regression to assess the association between occupational exposure to PAHs and craniosynostosis. Results: The prevalence of exposure was 5.3% in case mothers (16/300) and 3.7% in control mothers (107/2,886). We observed a positive association between exposure to PAHs during the 1 month before conception through the third month of pregnancy and craniosynostosis (odds ratio [OR]51.75; 95% confidence interval [CI], 1.01-3.05) after adjusting for maternal age and maternal education. The number of cases for each craniosynostosis subtype limited subtype analyses to sagittal craniosynostosis; the odds ratio remained similar (OR51.76, 95% CI, 0.82-3.75), but was not significant. Conclusion: Our findings support a moderate association between maternal occupational exposure to PAHs and craniosynostosis. Additional work is needed to better characterize susceptibility and the role PAHs may play on specific craniosynostosis subtypes. [Description provided by NIOSH]
• Subjects:
  Epidemiology Hydrocarbons Occupational Exposure Occupational Health Polycyclic Aromatic Hydrocarbons Pregnancy Safety
• Keywords:
  Author Keywords: Craniosynostosis Birth Defects Case-control Congenital Effects Occupational Exposure PAH Polycyclic Aromatic Hydrocarbon Polycyclic Aromatic Hydrocarbons Prenatal Exposure
• ISSN:
  1542-0752
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Journal Article
• Place as Subject:
  Iowa ; Ohio ; OSHA Region 5 ; OSHA Region 6 ; OSHA Region 7 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  55-60
• Volume:
  106
• Issue:
  1
• NIOSHTIC Number:
  nn:20046472
• Citation:
  Birth Defects Res A Clin Mol Teratol 2016 Jan; 106(1):55-60
• Contact Point Address:
  Philip J. Lupo, One Baylor Plaza, Houston TX, 77030, BCM305
• Email:
  philip.lupo@bcm.edu
• Federal Fiscal Year:
  2016
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  Battelle
• Peer Reviewed:
  True
• Start Date:
  20011001
• Source Full Name:
  Birth Defects Research Part A: Clinical and Molecular Teratology
• End Date:
  20060630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c65150256c9a8a4d7db6c85daa9b13b5bfa2d21c80915cd816b5ee6ab9d9975bb5ca15041b171a6160dd8ec7e890421c073c4e4141b4ef75e35781d43c39ab72
• Download URL:
  https://stacks.cdc.gov/view/cdc/201520/cdc_201520_DS1.pdf
• File Type:
  [PDF - 82.81 KB ]