Comparison of acute health effects from exposures to diesel and biodiesel fuel emissions

Details

• Personal Author:
  Burgess JL ; Hu C ; Lee VST ; Littau SR ; Lutz EA ; Mehus AA ; Reed RJ
• Description:
  Objective: To investigate the comparative acute health effects associated with exposures to diesel and 75% biodiesel/25% diesel (B75) blend fuel emissions. Methods: We analyzed multiple health endpoints in 48 healthy adults before and after exposures to diesel and B75 emissions in an underground mine setting - lung function, lung and systemic inflammation, novel biomarkers of exposure, and oxidative stress were assessed. Results: B75 reduced respirable diesel particulate matter by 20%. Lung function declined significantly more after exposure to diesel emissions. Lung inflammatory cells along with sputum and plasma inflammatory mediators increased significantly to similar levels with both exposures. Urinary 8-hydroxydeoxyguanosine, a marker of oxidative stress, was not significantly changed after either exposure. Conclusions: Use of B75 lowered respirable diesel particulate matter exposure and some associated acute health effects, although lung and systemic inflammation were not reduced compared with diesel use. Description provided by NIOSH
• Subjects:
  • Biomarkers
  • Fuel Oils
  • Immune System
  • Lung
  • Mining
  • Occupational Health
  • Particulate Matter
  • Respiratory System
  • Safety
  • Toxicology
  More +
• Keywords:
  • Toxicology
  • Diesel emissions
  • Particulates
  • Fuels
  • Lung function
  • Respiratory irritants
  • Immune reaction
  • Oxidative stress
  • Sputum analysis
  • Biomarkers
  More +
• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant ; Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Arizona ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  57
• Issue:
  7
• NIOSHTIC Number:
  nn:20046406
• Citation:
  J Occup Environ Med 2015 Jul; 57(7):705-712
• Contact Point Address:
  Jefferey L. Burgess, MD, MS, MPH, Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N Martin, Tucson, AZ 85724
• Email:
  jburgess@email.arizona.edu
• Federal Fiscal Year:
  2015
• NORA Priority Area:
  Mining
• Performing Organization:
  University of Arizona, Tucson
• Peer Reviewed:
  True
• Start Date:
  20120701
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20150630
• Download URL:
  https://stacks.cdc.gov/view/cdc/201474/cdc_201474_DS1.pdf
• File Type:
  [PDF - 170.66 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ba1dff6946303a1bb9e6bfc3bca55262ceae8d57ea15fb27a6e0de2234eef9896c191b3ab8601f8f0c7bae2dd4b84a27362e6a58349a13e79b3e94514026cef9