Comparison of acute health effects from exposures to diesel and biodiesel fuel emissions

Details

• Personal Author:
  Burgess JL ; Hu C ; Lee VST ; Littau SR ; Lutz EA ; Mehus AA ; Reed RJ
• Description:
  Objective: To investigate the comparative acute health effects associated with exposures to diesel and 75% biodiesel/25% diesel (B75) blend fuel emissions. Methods: We analyzed multiple health endpoints in 48 healthy adults before and after exposures to diesel and B75 emissions in an underground mine setting - lung function, lung and systemic inflammation, novel biomarkers of exposure, and oxidative stress were assessed. Results: B75 reduced respirable diesel particulate matter by 20%. Lung function declined significantly more after exposure to diesel emissions. Lung inflammatory cells along with sputum and plasma inflammatory mediators increased significantly to similar levels with both exposures. Urinary 8-hydroxydeoxyguanosine, a marker of oxidative stress, was not significantly changed after either exposure. Conclusions: Use of B75 lowered respirable diesel particulate matter exposure and some associated acute health effects, although lung and systemic inflammation were not reduced compared with diesel use. [Description provided by NIOSH]
• Subjects:
  Biomarkers Fuel Oils Immune System Lung Mining Occupational Health Particulate Matter Respiratory System Safety Toxicology Vehicle Emissions

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• Keywords:
  Diesel Emissions Fuels Immune Reaction Lung Function Oxidative Stress Particulates Respiratory Irritants Sputum Analysis Underground Mining
• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant ; Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Arizona ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  57
• Issue:
  7
• NIOSHTIC Number:
  nn:20046406
• Citation:
  J Occup Environ Med 2015 Jul; 57(7):705-712
• Contact Point Address:
  Jefferey L. Burgess, MD, MS, MPH, Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N Martin, Tucson, AZ 85724
• Email:
  jburgess@email.arizona.edu
• Federal Fiscal Year:
  2015
• NORA Priority Area:
  Mining
• Performing Organization:
  University of Arizona, Tucson
• Peer Reviewed:
  True
• Start Date:
  20120701
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20150630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ba1dff6946303a1bb9e6bfc3bca55262ceae8d57ea15fb27a6e0de2234eef9896c191b3ab8601f8f0c7bae2dd4b84a27362e6a58349a13e79b3e94514026cef9
• Download URL:
  https://stacks.cdc.gov/view/cdc/201474/cdc_201474_DS1.pdf
• File Type:
  [PDF - 170.66 KB ]