Prepubertal serum concentrations of organochlorine pesticides and age at sexual maturity in Russian boys

Details

• Personal Author:
  Altshul LM ; Birnbaum LS ; Burns JS ; Hauser R ; Korrick SA ; Lam T ; Lee MM ; Patterson DG Jr. ; Revich B ; Sergeyev O ; Williams PL
• Description:
  Background: Few human studies have evaluated the impact of childhood exposure to organochlorine pesticides (OCP) on pubertal development. Objective: To evaluate associations of serum OCP concentrations [hexachlorobenzene (HCB), beta-hexachlorocyclohexane (beta-HCH), and p,p-dichlorodiphenyldichloroethylene (p,p'-DDE)] with age at attainment of sexual maturity among boys. Methods: From 2003-2005, 350 8-9 year-old boys from Chapaevsk, Russia with measured OCPs were enrolled and followed annually for eight years. We used multivariable interval-censored models to evaluate associations of OCPs (quartiles) with three physician-assessed measures of sexual maturity: Tanner stage 5 for genitalia growth, Tanner stage 5 for pubic hair growth, or testicular volume (TV) >/= 20 mL in either testis. Results: In adjusted models, boys with higher HCB concentrations achieved sexual maturity reflected by TV >/= 20 mL a mean of 3.1 months (95% CI: -1.7, 7.8), 5.3 months (95% CI: 0.6, 10.1), and 5.0 months (95% CI: 0.2, 9.8) later for quartiles Q2, Q3, and Q4, respectively compared to Q1 (trend p=0.04). Tanner stage 5 for genitalia growth was attained a mean of 2.2 months (95% CI: -3.1, 7.5), 5.7 months (95% CI: 0.4, 11.0), and 3.7 months (-1.7, 9.1) later for quartiles Q2, Q3, and Q4 respectively of beta-HCH as compared to Q1 (trend p=0.09). Tanner stage 5 for pubic hair growth occurred 6-9 months later on average for boys in the highest vs. lowest quartile for HCB (trend p<0.001), beta-HCH (trend p=0.01), and p,p'-DDE (trend p=0.04). No associations were observed between p,p'-DDE and Tanner stage 5 for genitalia growth or TV >/= 20 mL. Conclusions and relevance: Higher prepubertal serum HCB and beta-HCH concentrations were associated with a later age at attainment of sexual maturity. Only the highest quartile of serum p,p'-DDE was associated with later pubic hair maturation. [Description provided by NIOSH]
• Subjects:
  Aging Agriculture Benzene Chlorine Compounds Environmental Exposure Ethylenes Hexanes Insecticides Occupational Health Safety Sex Characteristics Urogenital Diseases Urogenital System

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• Keywords:
  Age-groups Agricultural-chemicals Analytical-models Benzenes Children Chlorinated-benzenes Chlorinated-diphenyls Chlorinated-ethylenes Chlorinated-hexanes Developmental-disorders Environmental-exposure Humans Organo-chlorine-compounds Pesticides Pesticides-and-agricultural-chemicals Reproductive-hazards Reproductive-system-disorders Sex-factors Testes

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• ISSN:
  0091-6765
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Massachusetts ; North Carolina ; OSHA Region 1 ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  123
• Issue:
  11
• NIOSHTIC Number:
  nn:20046236
• Citation:
  Environ Health Perspect 2015 Nov; 123(11):1216-1221
• Contact Point Address:
  Russ Hauser, Environmental and Occupational Medicine and Epidemiology Program, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Building 1, Room 1409, Boston, MA 02115 USA
• Email:
  rhauser@hsph.harvard.edu
• CAS Registry Number:
  Cyclohexane, 1,2,3,4,5,6-hexachloro- (CAS RN 608-73-1) ; Hexachlorobenzene (CAS RN 118-74-1) ; p,p′-DDE (CAS RN 72-55-9)
• Federal Fiscal Year:
  2016
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Health Perspectives
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f5b6e2f12215f1f3538f34e21ab9093cfd81448f7282c0959f11f3de21cd7d5254dd3a8a1f91b412afbcbee31dd367837eb1e4785e5cb2ad06d131e1b86d39cf
• Download URL:
  https://stacks.cdc.gov/view/cdc/201349/cdc_201349_DS1.pdf
• File Type:
  [PDF - 229.12 KB ]